{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T16:30:18Z","timestamp":1723221018177},"reference-count":43,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2013,9,18]],"date-time":"2013-09-18T00:00:00Z","timestamp":1379462400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dog's mercury (<jats:italic>Mercurialis perennis<\/jats:italic> L.) is an old medicinal plant, nowadays used in complementary medicine. Aqueous fermented extracts of the plant are being mainly applied in remedies to treat external inflammations, but a thorough phytochemical characterization is still lacking. Therefore, the conversion of characteristic compound classes from <jats:italic>M. perennis<\/jats:italic> extracts during fermentation and storage was investigated. The microbial transformation of the two main depsides phaselic acid (=(2<jats:italic>R<\/jats:italic>)\u2010<jats:italic>O<\/jats:italic>\u2010[(<jats:italic>E<\/jats:italic>)\u2010caffeoyl]malic acid; <jats:bold>1<\/jats:bold>) and mercurialis acid (=(2<jats:italic>R<\/jats:italic>)\u2010[(<jats:italic>E<\/jats:italic>)\u2010caffeoyloxy]glutaric acid; <jats:bold>2<\/jats:bold>) was monitored by HPLC\u2010DAD. The degradation followed a second\u2010order kinetic, and the calculated half\u2010life periods of both constituents were 67 and 30\u2005months, respectively. Several depside metabolites were detected by GC\/MS in AcOEt extracts as <jats:italic><jats:sup>t<\/jats:sup><\/jats:italic>BuMe<jats:sub>2<\/jats:sub>Si (TBDMS) derivatives after derivatization, mainly dihydrocinnamic acids. Moreover, numerous <jats:italic>\u03b1<\/jats:italic>\u2010hydroxy acids were found, allegedly as degradation products from amino acids or peptides. The microbial alteration of the main alkaloid hermidin was also examined. After three days of fermentation, three novel N\u2010metabolites were formed and thoroughly assigned in CH<jats:sub>2<\/jats:sub>Cl<jats:sub>2<\/jats:sub> extracts as a mixture of 3\u2010ethylhermidin, 3\u2010ethylhermidin quinone, and (<jats:italic>E<\/jats:italic>\/<jats:italic>Z<\/jats:italic>)\u20103\u2010ethylidenehermidin by GC\/MS and NMR methods, as well as by means of total synthesis. A mechanism for the formation of these N\u2010metabolites starting from dimeric hermidin oxidation products is proposed. The obtained results reveal the complex pathways plant constituents may undergo during the fermentation of the extracts.<\/jats:p>","DOI":"10.1002\/cbdv.201200424","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T11:48:56Z","timestamp":1381232936000},"page":"1706-1723","source":"Crossref","is-referenced-by-count":13,"title":["Metabolic Fate of Depsides and Alkaloid Constituents in Aqueous Extracts from <i>Mercurialis perennis<\/i> L. during Fermentation"],"prefix":"10.1002","volume":"10","author":[{"given":"Peter","family":"Lorenz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00fcrgen","family":"Conrad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian C.","family":"Stintzing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,9,18]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2009.07.001"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2010.06.005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399508"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1541-4337.2002.tb00004.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2012.01.027"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2010.12.003"},{"key":"e_1_2_1_7_2","unstructured":"GHP German Homoeopathic Pharmacopoeia Hom\u00f6opathisches Arzneibuch Spezielle Herstellungsvorschriften Vorschrift 34c Deutscher Apotheker\u2010Verlag Stuttgart Govi\u2010Pharamzeutischer Verlag Eschborn 2008."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00399499"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2009.07.009"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000176260"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fm.2006.07.006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.09.067"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2009.03.025"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-008-9095-3"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf303165w"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.02.024"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.02.001"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf2041643"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2359"},{"key":"e_1_2_1_20_2","first-page":"331","volume":"67","author":"Schwarzenberger M.","year":"2012","journal-title":"Pharmazie"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1331476"},{"key":"e_1_2_1_22_2","unstructured":"G.Madaus \u2018Lehrbuch der biologischen Heilmittel 1979\u2019 2. 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