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A novel system that couples an online mass spectrometer with an odorant pulse delivery olfactometer was employed to characterize intranasal odorant concentrations of butane\u20102,3\u2010dione (or butanedione, commonly known as diacetyl) at the interior <jats:italic>naris<\/jats:italic> and the olfactory cleft. Volunteers (<jats:italic>n<\/jats:italic>=12) were asked to perform different modes of sniffing in relation to the sniff intensity that were categorized as \u2018normal\u2019, \u2018rapid\u2019 and \u2018forced\u2019. The highest concentrations of butanedione at both positions in the nose were observed during normal sniffing, with the lowest concentrations correlating with periods of forced sniffs. This corresponded to the panelists' ratings that normal sniffing elicited the highest odor intensities. These feasibility assessments pave the way for more in\u2010depth analyses with a variety of odorants of different chemical classes at various intranasal positions, to investigate the passage and uptake of odorants within the nasal cavity.<\/jats:p>","DOI":"10.1002\/cbdv.201300320","type":"journal-article","created":{"date-parts":[[2014,4,7]],"date-time":"2014-04-07T07:53:17Z","timestamp":1396857197000},"page":"619-638","source":"Crossref","is-referenced-by-count":15,"title":["Intranasal Odorant Concentrations in Relation to Sniff Behavior"],"prefix":"10.1002","volume":"11","author":[{"given":"Jonathan","family":"Beauchamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy","family":"Scheibe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Buettner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,4,7]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00115.2003"},{"key":"e_1_2_1_2_2","unstructured":"J. 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