{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:08:28Z","timestamp":1776283708525,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T00:00:00Z","timestamp":1411084800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plants from the genus <jats:italic>Ferula<\/jats:italic> L. (Apiaceae) were used for various purposes in traditional medicine of different nations throughout the history. <jats:italic>Ferula heuffelii<\/jats:italic> <jats:sc>Griseb<\/jats:sc>. ex <jats:sc>Heuffel<\/jats:sc> is a perennial species endemic for Balkan peninsula. Ten compounds which belong to classes of prenyl\u2010furocoumarin\u2010, prenyl\u2010dihydrofurochromone\u2010, prenyl\u2010benzoyl\u2010 and prenyl\u2010benzoylfuranone\u2010type sesquiterpenoids, as well as sesquiterpene coumarins and phenylpropanoids, were, for the first time, isolated from the CHCl<jats:sub>3<\/jats:sub> extract of the underground parts of this plant and identified. Furthermore, extract and three isolated compounds, <jats:italic>i.e.<\/jats:italic>, latifolone (<jats:bold>1<\/jats:bold>), dshamirone (<jats:bold>4<\/jats:bold>), and (2<jats:italic>S<\/jats:italic>*,3<jats:italic>R<\/jats:italic>*)\u20102\u2010[(3<jats:italic>E<\/jats:italic>)\u20104,8\u2010dimethylnona\u20103,7\u2010dien\u20101\u2010yl]\u20102,3\u2010dihydro\u20107\u2010hydroxy\u20102,3\u2010dimethylfuro[3,2\u2010<jats:italic>c<\/jats:italic>]coumarin (<jats:bold>6<\/jats:bold>) were, for the first time, evaluated for their <jats:italic>in vitro<\/jats:italic> antispasmodic activities in three experimental models: spontaneous contraction, and ACh\u2010 and KCl\u2010induced contraction of an isolated rat ileum. The extract (0.1\u20131.3\u2005mg\/ml) and compound <jats:bold>6<\/jats:bold> (1\u201310\u2005\u03bcg\/ml) exhibited dose\u2010dependent effect in all three models. Compound <jats:bold>1<\/jats:bold> (1\u20136\u2005\u03bcg\/ml) affected spontaneous contractions and those induced by KCl, while compound <jats:bold>4<\/jats:bold> (8\u2005\u03bcg\/ml) displayed only moderate activity with ACh\u2010induced contractions. It can be concluded that tested compounds contribute to exhibited antispasmodic activity of crude extract. Additionally, extract (0.1\u20131.3\u2005mg\/ml) was tested for <jats:italic>in vitro<\/jats:italic> relaxant activity on an isolated rat trachea, and relaxed the KCl\u2010induced contractions in a dose\u2010dependent manner.<\/jats:p>","DOI":"10.1002\/cbdv.201400094","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T10:07:50Z","timestamp":1411121270000},"page":"1417-1427","source":"Crossref","is-referenced-by-count":17,"title":["Chloroform Extract of Underground Parts of <i>Ferula heuffelii<\/i>: Secondary Metabolites and Spasmolytic Activity"],"prefix":"10.1002","volume":"11","author":[{"given":"Ivan","family":"Pavlovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksej","family":"Kruni\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dejan","family":"Nikoli\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjana","family":"Radenkovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzana","family":"Brankovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Niketi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Petrovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1139\/b00-029"},{"key":"e_1_2_1_2_2","unstructured":"O.Drude in \u2018Die nat\u00fcrlichen Pflanzenfamilien 3(8)\u2019 Ed. 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