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The availability of a selective radioligand for the D<jats:sub>4<\/jats:sub>receptor with suitable properties for positron emission tomography (PET) would help resolve issues of D<jats:sub>4<\/jats:sub>receptor localization in the brain, and the presumed diurnal change of expressed protein in the eye and pineal gland. We report here on<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>characteristics of the high\u2010affinity D<jats:sub>4<\/jats:sub>receptor\u2010selective ligand<jats:italic>N<\/jats:italic>\u2010{2\u2010[4\u2010(3\u2010cyanopyridin\u20102\u2010yl)piperazin\u20101\u2010yl]ethyl}\u20103\u2010[<jats:sup>11<\/jats:sup>C]methoxybenzamide ([<jats:sup>11<\/jats:sup>C]<jats:bold>2<\/jats:bold>) in rat. The results provide new insights on the<jats:italic>in vitro<\/jats:italic>properties that a brain PET dopamine D<jats:sub>4<\/jats:sub>radioligand should possess in order to have improved<jats:italic>in vivo<\/jats:italic>utility in rodents.<\/jats:p>","DOI":"10.1002\/cbdv.201400178","type":"journal-article","created":{"date-parts":[[2014,9,19]],"date-time":"2014-09-19T10:07:50Z","timestamp":1411121270000},"page":"1298-1308","source":"Crossref","is-referenced-by-count":4,"title":["<i>In Vitro<\/i>and<i>In Vivo<\/i>Evaluation of<i>N<\/i>\u2010{2\u2010[4\u2010(3\u2010Cyanopyridin\u20102\u2010yl)piperazin\u20101\u2010yl]ethyl}\u20103\u2010[<sup>11<\/sup>C]methoxybenz\u00adamide, a Positron Emission Tomography (PET) Radioligand for Dopamine D<sub>4<\/sub>Receptors, in Rodents"],"prefix":"10.1002","volume":"11","author":[{"given":"Marcello","family":"Leopoldo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Svetlana V.","family":"Selivanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrienne","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enza","family":"Lacivita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Schetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon M.","family":"Ametamey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9,19]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002642"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1081\/RRS-200032088"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.05148.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00562-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","unstructured":"J. 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