{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T06:59:20Z","timestamp":1777964360704,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three new diphenyl ether derivatives, talaromycins A\u2013C (<jats:bold>1<\/jats:bold>\u2013<jats:bold>3<\/jats:bold>, resp.), together with six known analogs, <jats:bold>4<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>, were isolated from a gorgonian\u2010derived fungus, <jats:italic>Talaromyces<\/jats:italic> sp. The structures of the new compounds were determined by analysis of extensive NMR spectroscopic data. All of the isolated metabolites, <jats:bold>1<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>, were evaluated for their cytotoxic and antifouling activities. Compound <jats:bold>4<\/jats:bold> exhibited pronounced cytotoxicity against the tested human cell lines with the <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> values ranging from 4.3 to 9.8\u2005\u03bc<jats:sc>M<\/jats:sc>. Compounds <jats:bold>3, 5, 8<\/jats:bold>, and <jats:bold>9<\/jats:bold> showed potent antifouling activities against the larval settlement of the barnacle <jats:italic>Balanus amphitrite<\/jats:italic> with the <jats:italic>EC<\/jats:italic><jats:sub>50<\/jats:sub> values ranging from 2.2 to 4.8\u2005\u03bcg\/ml.<\/jats:p>","DOI":"10.1002\/cbdv.201400267","type":"journal-article","created":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T07:47:38Z","timestamp":1426232858000},"page":"443-450","source":"Crossref","is-referenced-by-count":37,"title":["Bioactive Diphenyl Ether Derivatives from a Gorgonian\u2010Derived Fungus <i>Talaromyces<\/i> sp."],"prefix":"10.1002","volume":"12","author":[{"given":"Min","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Lun","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Gang","family":"She","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang\u2010Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,3,13]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1039\/C2NP20112G"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1021\/np300377b"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/np300707x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/np300103w"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/np100641b"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1021\/jf500248z"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1021\/np5001686"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.44.144"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/np980496m"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(01)92051-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)80905-7"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/jo062231f"},{"key":"e_1_2_1_13_2","first-page":"589","volume":"48","author":"Alley M. C.","year":"1988","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00227-003-1077-9"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201400267","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201400267","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T05:36:39Z","timestamp":1700631399000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201400267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1002\/cbdv.201400267"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201400267","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3]]}}}