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Among them, 4\u2010oxo\u20104<jats:italic>H<\/jats:italic>\u20101\u2010benzopyran\u20108\u2010carbaldehydes <jats:bold>11a<\/jats:bold>\u2013<jats:bold>11g<\/jats:bold> were most promising, and they demonstrated better activities and selectivities comparable to those the reference ribarivin, a nucleoside antiviral agent. 3\u2010(4\u2010Bromophenyl)\u20107\u2010hydroxy\u20104\u2010oxo\u20104<jats:italic>H<\/jats:italic>\u20101\u2010benzopyran\u20108\u2010carboxaldehyde (<jats:bold>11c<\/jats:bold>) displayed the best inhibitory activity (<jats:italic>EC<\/jats:italic><jats:sub>50<\/jats:sub>, 29.0\u2005\u03bc<jats:sc>M<\/jats:sc>) and selectivity index (<jats:italic>SI<\/jats:italic>&gt;10.3). Analysis of the structure\uf8ffactivity relationships (SAR) indicated that both the non\u2010naturally\u2010occurring Br\u2010substituted <jats:italic>B<\/jats:italic>\u2010ring and appropriate CHO and OH groups on the <jats:italic>A<\/jats:italic>\u2010ring might be critical for the activity and selectivity against H1N1 TR influenza viruses.<\/jats:p>","DOI":"10.1002\/cbdv.201400337","type":"journal-article","created":{"date-parts":[[2015,4,16]],"date-time":"2015-04-16T13:10:42Z","timestamp":1429189842000},"page":"685-696","source":"Crossref","is-referenced-by-count":14,"title":["Novel Daidzein Analogs and Their <i>in Vitro<\/i> Anti\u2010Influenza Activities"],"prefix":"10.1002","volume":"12","author":[{"given":"Shu\u2010Ting","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsin\u2010Yi","family":"Hsiung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen\u2010Hsin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen\u2010Wen","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An\u2010Rong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,16]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2175"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08157"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/446358a"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki018"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp0900648"},{"key":"e_1_2_1_6_2","first-page":"1042","volume":"301","author":"Gooskens J.","year":"2009","journal-title":"J. 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