{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T21:19:05Z","timestamp":1785878345585,"version":"3.56.0"},"reference-count":58,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T00:00:00Z","timestamp":1447632000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two lichen metabolites, rhizonaldehyde (<jats:bold>1<\/jats:bold>) and rhizonyl alcohol (<jats:bold>2<\/jats:bold>), were isolated from the acetone extract of <jats:italic>Lobaria pulmonaria<\/jats:italic> by chromatographic methods, and their chemical structures were determined by UV\/VIS, IR, and 1D\u2010 and 2D\u2010NMR spectroscopic methods. The gastroprotective and <jats:italic>in vivo<\/jats:italic> antioxidant activities of extracts of <jats:italic>L. pulmonaria<\/jats:italic> and its metabolites, <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold>, were investigated in indomethacin\u2010induced ulcer models in rats. The gastric lesions were significantly reduced by acetone, hexane, and CHCl<jats:sub>3<\/jats:sub> extracts, with 75.3\u201341.5% inhibition. Rhizonyl alcohol (<jats:bold>2<\/jats:bold>) significantly reduced the gastric lesions with an inhibition rate of 84.6\u201342.8%, whereas rhizonaldehyde (<jats:bold>1<\/jats:bold>) significantly increased the gastric lesions. Antioxidant parameters and myeloperoxidase activities were also evaluated in the gastric tissues of the rats. Indomethacin caused oxidative stress, which resulted in lipid peroxidation in gastric tissues by decreasing the levels of the antioxidants as compared to healthy rat tissues. In contrast to indomethacin, all extracts and rhizonyl alcohol (<jats:bold>2<\/jats:bold>) caused a significant decrease in lipid peroxidation levels and an increase in antioxidant parameters, superoxide dismutase, glutathione peroxidase, and glutathione\u2010<jats:italic>S<\/jats:italic>\u2010transferase, and reduced glutathione in gastric tissues. The administration of rhizonyl alcohol (<jats:bold>2<\/jats:bold>) also resulted in a decrease in gastric myeloperoxidase activity increased by indomethacin. The gastroprotective effect of rhizonyl alcohol (<jats:bold>2<\/jats:bold>) can be attributed to its antioxidant properties and its suppressing effect on neutrophil infiltration into gastric tissues.<\/jats:p>","DOI":"10.1002\/cbdv.201400432","type":"journal-article","created":{"date-parts":[[2015,11,16]],"date-time":"2015-11-16T11:17:28Z","timestamp":1447672648000},"page":"1756-1767","source":"Crossref","is-referenced-by-count":12,"title":["Gastroprotective and Antioxidant Effects of <i>Lobaria pulmonaria<\/i> and Its Metabolite Rhizonyl Alcohol on Indomethacin\u2010Induced Gastric Ulcer"],"prefix":"10.1002","volume":"12","author":[{"given":"Fadime","family":"Atalay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fehmi","family":"Odabasoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mesut","family":"Halici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmet","family":"Cakir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Cadirci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Aslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozlem","family":"Aydin\u2005Berktas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cavit","family":"Kazaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,16]]},"reference":[{"key":"e_1_2_1_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(90)90050-7"},{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00547-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(02)00995-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064751","volume":"8","author":"Al Batran R.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.17.7915"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.09.036"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9120(99)00075-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198809000-00015"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1159\/000200718"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(96)00625-9"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/1998\/398384"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(98)00237-3"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02091537"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018875932503"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000007506"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","unstructured":"S.Huneck I.Yoshimura \u2018Identification of Lichen Substances\u2019 Springer Berlin 1996.","DOI":"10.1007\/978-3-642-85243-5"},{"key":"e_1_2_1_17_2","first-page":"86","volume":"439","author":"Dilsizo\u011flu A.","year":"2004","journal-title":"T\u00fcbitak Bilim ve Teknik"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40421999000100018"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)82466-8"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-009-0367-z"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082293"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.43.1388"},{"key":"e_1_2_1_23_2","first-page":"647","volume":"35","author":"Atalay F.","year":"2011","journal-title":"Turk. J. Chem."},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2005.07.002"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.06.043"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2675"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1078\/094471103322331539"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90253-7"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114510003107"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.19.716"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309104012"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-007-0263-9"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.3.344"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1007\/PL00000278"},{"key":"e_1_2_1_35_2","first-page":"265","volume":"4","author":"Djahanguiri B.","year":"1969","journal-title":"Scand. J. Gastroenterol."},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02208673"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb15066.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0550"},{"key":"e_1_2_1_39_2","volume":"283","author":"Filaretova L.","year":"2002","journal-title":"Am. J. Physiol. \u2013 Gastr. Liver Physiol."},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2006.11.018"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-010-0504-y"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2001.02592.x"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bmb.a072625"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1258\/0004563011900911"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6972"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1159\/000201464"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.075"},{"key":"e_1_2_1_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3841.2012.02920.x"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1560\/RRXU-EX5Y-QRXK-H1HA"},{"key":"e_1_2_1_50_2","unstructured":"\u2018Guide to the Care and Use of Experimental Animals\u2019 Eds. E.\u2005D. Olfert B.\u2005M. Cross A.\u2005A. McWilliam Canadian Council on Animal Care Ottawa 1993 Vol.\u20051."},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(68)90092-4"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/34.3.497"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(76)90747-6"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(81)77053-8"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(85)13062-4"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12506462"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201400432","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201400432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,22]],"date-time":"2023-11-22T14:01:58Z","timestamp":1700661718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201400432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":58,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/cbdv.201400432"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201400432","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11]]}}}