{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:40:52Z","timestamp":1761709252106},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T00:00:00Z","timestamp":1473465600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>Saint Peter and Saint Paul's Archipelago is a collection of 15 islets and rocks remotely located in the equatorial Atlantic Ocean. In this particular site, the present project intended to assess the biodiversity and biotechnological potential of bacteria from the actinomycete group. This study presents the first results of this assessment. From 21 sediment samples, 268 strains were isolated and codified as <jats:styled-content style=\"fixed-case\">BRA<\/jats:styled-content> followed by three numbers. Of those, 94 strains were grown in liquid media and submitted to chemical extractions with Ac<jats:styled-content style=\"fixed-case\">OE<\/jats:styled-content>t (A), Bu<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> (B), and Me<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> (M). A total of 224 extracts were screened for their cytotoxic activity and 41 were significantly active against <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>\u2010116 cancer cells. The obtained <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> values ranged from 0.04 to 31.55 \u03bcg\/ml. The <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> dereplication analysis of the active extracts showed the occurrence of several known anticancer compounds. Individual compounds, identified using <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> combined with analysis of the AntiMarin database, included saliniketals A and B, piericidins A and C and glucopiericidin A, staurosporine, <jats:italic>N<\/jats:italic>\u2010methylstaurosporine, hydroxydimethyl\u2010staurosporine and <jats:italic>N<\/jats:italic>\u2010carbamoylstaurosporine, salinisporamycin A, and rifamycins S and B. <jats:styled-content style=\"fixed-case\">BRA<\/jats:styled-content>\u2010199, identified as <jats:italic>Streptomyces<\/jats:italic> sp., was submitted to bioassay\u2010guided fractionation, leading to isolation of the bioactive piericidins A and C, glucopiericidin, and three known diketopiperazines, cyclo(<jats:sc>l<\/jats:sc>\u2010Phe\u2010<jats:italic>trans<\/jats:italic>\u20104\u2010<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content>\u2010<jats:sc>l<\/jats:sc>\u2010Pro), cyclo(<jats:sc>l<\/jats:sc>\u2010Phe\u2010<jats:sc>l<\/jats:sc>\u2010Pro), and cyclo(<jats:sc>l<\/jats:sc>\u2010Trp\u2010<jats:sc>l<\/jats:sc>\u2010Pro).<\/jats:p>","DOI":"10.1002\/cbdv.201500514","type":"journal-article","created":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T16:26:40Z","timestamp":1469464000000},"page":"1149-1157","source":"Crossref","is-referenced-by-count":13,"title":["Prospecting Anticancer Compounds in Actinomycetes Recovered from the Sediments of Saint Peter and Saint Paul's Archipelago, Brazil"],"prefix":"10.1002","volume":"13","author":[{"given":"Elthon G.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Institute of Marine Sciences LABOMAR Federal University of Cear\u00e1 Fortaleza CE 60165\u2010081 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria da Concei\u00e7\u00e3o M.","family":"Torres","sequence":"additional","affiliation":[{"name":"Department of Organic and Inorganic Chemistry Federal University of Cear\u00e1 Fortaleza CE 60021\u2010970 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison B.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Organic and Inorganic Chemistry Federal University of Cear\u00e1 Fortaleza CE 60021\u2010970 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larissa L. F.","family":"Colares","sequence":"additional","affiliation":[{"name":"Institute of Marine Sciences LABOMAR Federal University of Cear\u00e1 Fortaleza CE 60165\u2010081 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karine","family":"Pires","sequence":"additional","affiliation":[{"name":"Institute of Marine Sciences LABOMAR Federal University of Cear\u00e1 Fortaleza CE 60165\u2010081 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tito M. 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