{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:19:43Z","timestamp":1790173183957,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T00:00:00Z","timestamp":1473292800000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004543","name":"Chinese Scholarship Council","doi-asserted-by":"crossref","award":["201208330199"],"award-info":[{"award-number":["201208330199"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science Technology Department of Zhejiang Province","award":["2014C31127"],"award-info":[{"award-number":["2014C31127"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:p>In our continuing effort to discover natural product\u2010based pest management agents, derivatives of 3,5\u2010dimethoxystilbene were synthesized yielding 27 new and six known compounds. Compounds <jats:bold>11<\/jats:bold> and <jats:bold>12<\/jats:bold> showed strong <jats:italic>Aedes aegypti<\/jats:italic> larvicidal activity (<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> 45.31 and 49.93 \u03bc<jats:sc>m<\/jats:sc>, respectively). Furthermore, <jats:bold>11<\/jats:bold> and <jats:bold>12<\/jats:bold> exhibited high effectiveness against larvae of pesticide\u2010susceptible and pyrethroid\u2010resistant strains of <jats:italic>Ae<\/jats:italic>. <jats:italic>aegypti<\/jats:italic>; activity against the adult mosquitoes was low. Compounds <jats:bold>6f<\/jats:bold>,<jats:bold> 6g<\/jats:bold>, and <jats:bold>6i<\/jats:bold> at either 83.3 or 166.7 \u03bcg\/ml reduced the mobility of second\u2010stage juveniles (J2) of the root\u2010knot nematode (<jats:italic>Meloidogyne incognita<\/jats:italic>) that hatched from eggs immersed in the test compounds for 7 days. However, there was little or no effect on J2 placed directly into these compounds, and none of the analogs suppressed <jats:italic>M<\/jats:italic>. <jats:italic>incognita<\/jats:italic> egg hatch. The compounds were tested for inhibition of some agriculturally important fungi; <jats:bold>6a<\/jats:bold>,<jats:bold> 7a<\/jats:bold>, and <jats:bold>7e<\/jats:bold> demonstrated strong inhibition of <jats:italic>Colletotrichum<\/jats:italic> species. Activity of the stilbenes against some human pathogens was also explored; <jats:bold>11<\/jats:bold>,<jats:bold> 12<\/jats:bold>, and <jats:bold>16<\/jats:bold> showed moderate inhibitory activity against <jats:italic>Cryptococcus neoformans<\/jats:italic>,<jats:italic> Staphylococcus aureus<\/jats:italic>, methicillin\u2010resistant <jats:italic>S<\/jats:italic>. <jats:italic>aureus<\/jats:italic>, and <jats:italic>Mycobacterium intracellulare<\/jats:italic>. Except for <jats:bold>11<\/jats:bold> and <jats:bold>12<\/jats:bold>, which were active against mosquito larvae and some human pathogens, no single analog demonstrated activity in all the tests, indicating specific activities. Synthesis of the analogs and structure\u2013activity relationships are discussed.<\/jats:p>","DOI":"10.1002\/cbdv.201500516","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T14:16:42Z","timestamp":1469283402000},"page":"1165-1177","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and Biological Evaluation of 3,5\u2010Dimethoxystilbene Analogs"],"prefix":"10.1002","volume":"13","author":[{"given":"Jian\u2010Quan","family":"Weng","sequence":"first","affiliation":[{"name":"Natural Products Utilization Research Unit Agricultural Research Service U.S. Department of Agriculture P.O. 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