{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:07:48Z","timestamp":1780668468995,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2011\/13630\u20107"],"award-info":[{"award-number":["2011\/13630\u20107"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/10132\u20101"],"award-info":[{"award-number":["2013\/10132\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>In this article, the <jats:italic>in vitro<\/jats:italic> schistosomicidal effects of three Brazilian <jats:italic>Copaifera<\/jats:italic> oleoresins (<jats:italic>C<\/jats:italic>. <jats:italic>duckei<\/jats:italic>,<jats:italic> C<\/jats:italic>. <jats:italic>langsdorffii<\/jats:italic>, and <jats:italic>C<\/jats:italic>. <jats:italic>reticulata<\/jats:italic>) are reported. From these botanical sources, the oleoresin of <jats:italic>C<\/jats:italic>. <jats:italic>duckei<\/jats:italic> (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>d) demonstrated to be the most promising, displaying <jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> values of 75.8, 50.6, and 47.2 \u03bcg\/ml at 24, 48, and 72 h of incubation, respectively, against adult worms of <jats:italic>Schistosoma mansoni<\/jats:italic>, with a selectivity index of 10.26. Therefore, the major compounds from <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>d were isolated, and the diterpene, (\u2212)\u2010polyalthic acid (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content>), showed to be active (<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> values of 41.7, 36.2, and 33.4 \u03bcg\/ml, respectively, at 24, 48, and 72 h of incubation). Moreover, <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>d and <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> affected the production and development of eggs, and <jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>d modified the functionality of the tegument of <jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic>. Possible synergistic and\/or additive effects of this balsam were also verified when a mixture of the two of its main compounds (<jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> and <jats:italic>ent<\/jats:italic>\u2010labd\u20108(17)\u2010en\u201015,18\u2010dioic acid) in the specific proportion of 3:1 (<jats:italic>w<\/jats:italic>\/<jats:italic>w<\/jats:italic>) was tested. The obtained results indicate that <jats:styled-content style=\"fixed-case\">PA<\/jats:styled-content> should be considered for further investigations against <jats:italic>S<\/jats:italic>. <jats:italic>mansoni<\/jats:italic>, such as, synergistic (combination with praziquantel (<jats:styled-content style=\"fixed-case\">PZQ<\/jats:styled-content>)) and <jats:italic>in vivo<\/jats:italic> studies. It also shows that diterpenes are an important class of natural compounds for the investigation of agents capable of fighting the parasite responsible for human schistosomiasis.<\/jats:p>","DOI":"10.1002\/cbdv.201600065","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T08:16:57Z","timestamp":1469261817000},"page":"1348-1356","source":"Crossref","is-referenced-by-count":31,"title":["<i>Copaifera duckei<\/i> Oleoresin and Its Main Nonvolatile Terpenes: <i>In Vitro<\/i> Schistosomicidal Properties"],"prefix":"10.1002","volume":"13","author":[{"given":"Carly H. G.","family":"Borges","sequence":"first","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele G.","family":"Cruz","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza J.","family":"Carneiro","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas J. M.","family":"da Silva","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo 14040\u2010020, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jairo K.","family":"Bastos","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo 14040\u2010020, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise C.","family":"Tavares","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pollyanna F.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderlei","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de Ribeir\u00e3o Preto Universidade de S\u00e3o Paulo Ribeir\u00e3o Preto 14049\u2010900 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo C. S.","family":"Veneziani","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato L. T.","family":"Parreira","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni F.","family":"Caramori","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Santa Catarina Campus Universit\u00e1rio Trindade, CP 476 Florian\u00f3polis 88040\u2010900 SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucio R.","family":"Nagurniak","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Santa Catarina Campus Universit\u00e1rio Trindade, CP 476 Florian\u00f3polis 88040\u2010900 SC Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizandra G.","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio R.","family":"Ambr\u00f3sio","sequence":"additional","affiliation":[{"name":"N\u00facleo de Pesquisa em Ci\u00eancias Exatas e Tecnol\u00f3gicas Universidade de Franca Franca 14404\u2010600, SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003286"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules190915058"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.12.012"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201100336"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16010762"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.23"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14023395"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-011-2527-9"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules171112771"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003604"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2015.12.003"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-40422002000200016"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.007"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3244"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1295"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm201451h"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(98)00155-1"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.200490257"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)96940-6"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34399"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11418-006-0025-7"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2788"},{"key":"e_1_2_6_24_1","first-page":"1","volume":"6","author":"Meng Z.","year":"2015","journal-title":"Nat. Commun."},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja503972p"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762013000100010"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2.S1.S53"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2014.02.010"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.200900292"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.05.028"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21494"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00531499"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2006.06.004"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)61949-2"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2013.12.009"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.12.035"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0030052"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2009.06.005"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002617"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.06.013"},{"key":"e_1_2_6_41_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000086248"},{"key":"e_1_2_6_42_1","doi-asserted-by":"publisher","DOI":"10.2307\/3277120"},{"key":"e_1_2_6_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp980017s"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/j100007a062"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002140050021"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1139\/V09-008"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.1056"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevB.33.8822"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevA.38.3098"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.472460"},{"key":"e_1_2_6_51_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.467943"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.466059"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201600065","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201600065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:08:50Z","timestamp":1695712130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201600065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/cbdv.201600065"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201600065","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10]]}}}