{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:42:16Z","timestamp":1791484936571,"version":"4.3.4"},"reference-count":75,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Anadolu University Research Fund","award":["1404S135"],"award-info":[{"award-number":["1404S135"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>The genus <jats:italic>Centaurea<\/jats:italic> L. is one of the largest and important genera of Asteraceae family. <jats:italic>Centaurea<\/jats:italic> species have been widely used as herbal remedies in folk medicine for their antidandruff, antidiarrheic, antirheumatic, anti\u2010inflammatory, choleretic, diuretic, digestive, stomachic, astringent, antipyretic, cytotoxic, and antibacterial properties. <jats:italic>Centaurea baseri <\/jats:italic><jats:sc>Kose<\/jats:sc> &amp; <jats:sc>Alan<\/jats:sc> is a recently described local endemic species in Turkey and this is the first study on the chemical composition and bioactivity of its hydrodistilled essential oil and the crude extract. According to chromatospectral analysis, hexadecanoic acid (42.3%), nonacosane (8.2%), and heptacosane (8.0%) were the main compounds of the essential oil, while 16 compounds were determined in the Me<jats:styled-content style=\"fixed-case\">OH<\/jats:styled-content> extract using <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Furthermore, antimicrobial, antioxidant, and cytotoxic effects of the essential oil and the extract were evaluated in comparison with the standard agents. The extract showed strong antifungal effect against <jats:italic>Candida utilis<\/jats:italic> at the concentration of 60 \u03bcg\/ml (<jats:italic><jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><\/jats:italic>) where the <jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content> showed growth inhibition at the concentration of 47.00 \u03bcg\/ml (<jats:italic><jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><\/jats:italic>) against pathogen <jats:italic>Bacillus cereus<\/jats:italic>. Both the essential oil and the extract did not show any selective antioxidant properties. The extract showed remarkably selective cytotoxic properties against <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107, <jats:styled-content style=\"fixed-case\">PANC<\/jats:styled-content>\u20101, A549, and C6 glioma cells.<\/jats:p>","DOI":"10.1002\/cbdv.201600070","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T12:42:46Z","timestamp":1469191366000},"page":"1369-1379","source":"Crossref","is-referenced-by-count":30,"title":["Chemical Composition and Biological Activity of <i>Centaurea baseri<\/i>: New Species from Turkey"],"prefix":"10.1002","volume":"13","author":[{"given":"Yavuz B\u00fclent","family":"K\u00f6se","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Botany Faculty of Pharmacy Anadolu University TR\u201026470 Eskisehir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6kalp","family":"\u0130\u015fcan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Anadolu University TR\u201026470 Eskisehir"},{"name":"Yunus Emre Vocational School Anadolu University TR\u201026470 Eskisehir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatih","family":"G\u00f6ger","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Anadolu University TR\u201026470 Eskisehir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u015fen","family":"Akal\u0131n","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Pharmacy Anadolu University TR\u201026470 Eskisehir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bet\u00fcl","family":"Demirci","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Anadolu University TR\u201026470 Eskisehir"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemal H\u00fcsn\u00fc Can","family":"Ba\u015fer","sequence":"additional","affiliation":[{"name":"Department of Botany and Microbiology College of Pharmacy King Saud University Riyadh 11451 Saudi Arabia"},{"name":"Department of Pharmacognosy Faculty of Pharmacy Near East University 99138 Nicosia N. 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