{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:16:24Z","timestamp":1785129384771,"version":"3.55.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,11,2]],"date-time":"2016-11-02T00:00:00Z","timestamp":1478044800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>The essential oil compositions of the leaves of three related Myrtaceae species, namely <jats:italic>Syzygium aqueum<\/jats:italic>,<jats:italic> Syzygium samarangense<\/jats:italic> and <jats:italic>Eugenia uniflora<\/jats:italic>, were investigated using <jats:styled-content style=\"fixed-case\">GLC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GLC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">FID<\/jats:styled-content>. Altogether, 125 compounds were identified: <jats:italic>\u03b1<\/jats:italic>\u2010Selinene (13.85%), <jats:italic>\u03b2<\/jats:italic>\u2010caryophyllene (12.72%) and <jats:italic>\u03b2<\/jats:italic>\u2010selinene constitute the most abundant constituents in <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aqueum<\/jats:italic>. Germacrene D (21.62%) represents the major compound in <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>samarangense<\/jats:italic> whereas in <jats:italic>E<\/jats:italic>.\u00a0<jats:italic>uniflora<\/jats:italic>, spathulenol (15.80%) represents the predominant component. Multivariate chemometric analyses were used to discriminate the essential oils using hierarchical cluster analysis (<jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>) and principal component analysis (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) based on the chromatographic results. The antimicrobial activity of the popularly used <jats:italic>E<\/jats:italic>.\u00a0<jats:italic>uniflora<\/jats:italic> essential oil was assessed using broth microdilution method against six <jats:italic>Gram<\/jats:italic>\u2010positive, three <jats:italic>Gram<\/jats:italic>\u2010negative bacteria and two fungi. The oil showed moderate antimicrobial activity against <jats:italic>Bacillus licheniformis<\/jats:italic> exhibiting <jats:italic><jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content><\/jats:italic> and <jats:italic><jats:styled-content style=\"fixed-case\">MMC<\/jats:styled-content><\/jats:italic> of 0.63\u00a0mg\/ml. The cytotoxic activity of <jats:italic>E<\/jats:italic>.\u00a0<jats:italic>uniflora<\/jats:italic> essential oil was investigated against <jats:italic>Trypanosoma brucei brucei<\/jats:italic> (<jats:italic>T<\/jats:italic>.\u00a0<jats:italic>b<\/jats:italic>.\u00a0<jats:italic>brucei<\/jats:italic>) and <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107 cancer cell line using <jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content> assay. It showed moderate activity against <jats:styled-content style=\"fixed-case\">MCF<\/jats:styled-content>\u20107 cells with an <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> value of 76.40\u00a0\u03bcg\/ml. On the other hand, <jats:italic>T<\/jats:italic>.\u00a0<jats:italic>brucei<\/jats:italic> was highly susceptible to <jats:italic>E<\/jats:italic>.\u00a0<jats:italic>uniflora<\/jats:italic> essential oil with <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> of 11.20\u00a0\u03bcg\/ml, and a selectivity index of 6.82.<\/jats:p>","DOI":"10.1002\/cbdv.201600089","type":"journal-article","created":{"date-parts":[[2016,7,22]],"date-time":"2016-07-22T13:22:48Z","timestamp":1469193768000},"page":"1537-1550","source":"Crossref","is-referenced-by-count":56,"title":["Chemical Profiling of the Essential Oils of <i>Syzygium aqueum<\/i>,<i> Syzygium samarangense<\/i> and <i>Eugenia uniflora<\/i> and Their Discrimination Using Chemometric Analysis"],"prefix":"10.1002","volume":"13","author":[{"given":"Mansour","family":"Sobeh","sequence":"first","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology Heidelberg University Im Neuenheimer Feld 364 DE\u201069120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus Santhosh","family":"Braun","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology Heidelberg University Im Neuenheimer Feld 364 DE\u201069120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Krstin","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology Heidelberg University Im Neuenheimer Feld 364 DE\u201069120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadia S.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed L.","family":"Ashour","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia 11566 Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Wink","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Molecular Biotechnology Heidelberg University Im Neuenheimer Feld 364 DE\u201069120 Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,11,2]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016091631721"},{"key":"e_1_2_5_3_1","volume-title":"Handbook of Essential Oils: Science, Technology, and Applications","author":"Baser K. 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