{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:07:41Z","timestamp":1791310061455,"version":"4.3.1"},"reference-count":70,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,4]],"date-time":"2017-02-04T00:00:00Z","timestamp":1486166400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Lipophilic extractive metabolites in different parts of the shoot system (needles and defoliated twigs) of Korean pine, <jats:italic>Pinus koraiensis<\/jats:italic>, and Siberian pine, <jats:italic>Pinus sibirica<\/jats:italic>, were studied by <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>. Korean pine needles comprised mainly bornyl <jats:italic>p<\/jats:italic>\u2010coumarate, heterocyclic 15\u2010<jats:italic>O<\/jats:italic>\u2010functionalized labdane type acids (lambertianic acid), 10\u2010nonacosanol, sterols and their esters. While Siberian pine needles contained less bornyl <jats:italic>p<\/jats:italic>\u2010coumarate, lambertianic acid, sterols and their esters, but were richer in other 15\u2010<jats:italic>O<\/jats:italic>\u2010functionalized labdane type acids. The major components of the twig extract of <jats:italic>P<\/jats:italic>. <jats:italic>koraiensis<\/jats:italic> were lambertianic acid, abietane and isopimarane type acids, cembrane type alcohols, 8\u2010<jats:italic>O<\/jats:italic>\u2010functionalized labdanoids, sterols, sterol esters, and acylglycerols. The same extract of <jats:italic>P<\/jats:italic>. <jats:italic>sibirica<\/jats:italic> differed in larger amounts of other 15\u2010<jats:italic>O<\/jats:italic>\u2010functionalized labdane type acids and pinolenic acid glycerides, but in less quantities of cembranoids and 8\u2010<jats:italic>O<\/jats:italic>\u2010functionalized labdanoids. The labdane type pinusolic acid was detected for the first time in Korean pine. <jats:italic>P<\/jats:italic>. <jats:italic>koraiensis<\/jats:italic> was found to be unique in the genus for an ability to synthesize phyllocladane diterpenoids. The content of bound \u0394<jats:sup>5<\/jats:sup>\u2010unsaturated polymethylene\u2010interrupted fatty acids in the twig extracts of the both pines was similar or superior to that in their seed oil. Among the pines\u2019 metabolites tested isocembrol was strongest in inhibition of both <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase (<jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> 2.9 \u03bcg\/ml) and <jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content> production in activated macrophages (<jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> 3.6 \u03bcg\/ml).<\/jats:p>","DOI":"10.1002\/cbdv.201600203","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T07:18:43Z","timestamp":1469258323000},"source":"Crossref","is-referenced-by-count":21,"title":["Composition and Bioactivity of Lipophilic Metabolites from Needles and Twigs of Korean and Siberian Pines (<i>Pinus koraiensis <\/i><scp>Siebold<\/scp> &amp; <scp>Zucc<\/scp>. and <i>Pinus sibirica <\/i><scp>Du Tour<\/scp>)"],"prefix":"10.1002","volume":"14","author":[{"given":"Alexander V.","family":"Shpatov","sequence":"first","affiliation":[{"name":"Novosibirsk Institute of Organic Chemistry (NIOC) Acad. 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