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In this study, the synthesis of galactose and fructose esters of 5\u2010<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content> was planned to evaluate the role of glycoconjugation on the bioactivity of the parent drug. The antibacterial activity of the new compounds were evaluated against two <jats:italic>Gram<\/jats:italic>\u2010negative and two <jats:italic>Gram<\/jats:italic>\u2010positive species of bacteria, with a notable effect observed against <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Escherichia coli<\/jats:italic> in comparisons with the 5\u2010<jats:styled-content style=\"fixed-case\">ASA<\/jats:styled-content>. Cytotoxicity testing over <jats:styled-content style=\"fixed-case\">HT<\/jats:styled-content>\u201029 and 3T3 cell lines indicated that the toxicity of the new products against normal cells was significantly reduced compared with the original drug, whereas their activity against cancerous cells was slightly decreased. The anti\u2010inflammatory activity test in <jats:styled-content style=\"fixed-case\">RAW<\/jats:styled-content>264.7 macrophage cells indicated that the inhibition of nitric oxide by both of the monosaccharide conjugated derivatives was slightly improved in comparison with the non\u2010conjugated drug.<\/jats:p>","DOI":"10.1002\/cbdv.201600362","type":"journal-article","created":{"date-parts":[[2016,12,30]],"date-time":"2016-12-30T14:48:46Z","timestamp":1483109326000},"source":"Crossref","is-referenced-by-count":3,"title":["Synthesis and <i>in\u00a0vitro<\/i> Bioactivity Evaluation of New Galactose and Fructose Ester Derivatives of 5\u2010Aminosalicylic Acid"],"prefix":"10.1002","volume":"14","author":[{"given":"Samira","family":"Yousefi","sequence":"first","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saadi","family":"Bayat","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohd Basyaruddin Abdul","family":"Rahman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Malaysia"},{"name":"Enzyme and Microbial Technology Centre Faculty of Biotechnology and Biomolecular Sciences Universiti Putra Malaysia 43400 Serdang, Selangor Malaysia"},{"name":"Structural and Synthetic Biology Research Center Malaysia Genome Institute 43600 Bangi, Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zalikha","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilia","family":"Abdulmalek","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Universiti Putra Malaysia 43400 UPM Serdang, Selangor Malaysia"},{"name":"Enzyme and Microbial Technology Centre Faculty of Biotechnology and Biomolecular Sciences Universiti Putra Malaysia 43400 Serdang, Selangor Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.08.011"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.02.012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-011-1731-x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X11405250"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/135100010X12826446921707"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2006.08.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353806"},{"key":"e_1_2_7_9_1","first-page":"855","article-title":"Evaluation of 5\u2010aminosalicylic acid (5\u2010ASA) for cancer chemoprevention: Lack of efficacy against nascent adenomatous polyps in the ApcMin mouse","volume":"5","author":"Ritland S. 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