{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:57:55Z","timestamp":1769245075400,"version":"3.49.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Technology of Republic of Srpska","award":["19\/6-020\/961-110\/14"],"award-info":[{"award-number":["19\/6-020\/961-110\/14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>The present paper describes environmental and seasonal\u2010related chemical composition variations, vasorelaxant and angiotensin I\u2010converting enzyme (ACE) activities of essential oil from aerial parts of <jats:italic>Seseli pallasii <\/jats:italic><jats:sc>Besser<\/jats:sc>. The composition was analyzed by GC and GC\/MS. Monoterpenes were found to be the most abundant chemical class with <jats:italic>\u03b1<\/jats:italic>\u2010pinene (42.7\u00a0\u2013\u00a048.2%) as the most prevalent component. <jats:italic>Seseli pallasi<\/jats:italic> essential oil relaxed isolated endothelium\u2010intact mesenteric arteries rings precontracted with phenylephrine with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub>\u00a0=\u00a03.10\u00a0nl\/ml (<jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub>\u00a0=\u00a02.70\u00a0\u03bcg\/ml). Also, <jats:italic>S.\u00a0pallasii<\/jats:italic> essential oil was found to exhibit a dose\u2010dependent ACE inhibitory activity with an <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> value of 0.33\u00a0mg\/ml. <jats:italic>In silico<\/jats:italic> evaluation of ACE inhibitory activity of the individual components showed that spathulenol exhibited the best binding affinity with ACE, and the lowest binding energy of \u22127.5\u00a0kcal\/mol. The results suggested that combination of vasorelaxing and ACE inhibitory effects of the analyzed <jats:italic>S.\u00a0pallasii<\/jats:italic> essential oil might have the potential therapeutic significance in hypertension.<\/jats:p>","DOI":"10.1002\/cbdv.201600407","type":"journal-article","created":{"date-parts":[[2016,12,10]],"date-time":"2016-12-10T13:23:49Z","timestamp":1481376229000},"source":"Crossref","is-referenced-by-count":22,"title":["Variations in Chemical Composition, Vasorelaxant and Angiotensin I\u2010Converting Enzyme Inhibitory Activities of Essential Oil from Aerial Parts of <i>Seseli pallasii <\/i><scp>Besser<\/scp> (Apiaceae)"],"prefix":"10.1002","volume":"14","author":[{"given":"Relja","family":"Suru\u010di\u0107","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy University of Banja Luka\u2010Faculty of Medicine Save Mrkalja 14 78000 Banjaluka Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Kundakovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade\u2010Faculty of Pharmacy V.Stepe 450 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Branislava","family":"Laku\u0161i\u0107","sequence":"additional","affiliation":[{"name":"Department of Botany University of Belgrade\u2010Faculty of Pharmacy V.Stepe 450 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragana","family":"Drakul","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Eastern Sarajevo Studentska 7 Fo\u010da Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Slobodan R.","family":"Milovanovi\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Eastern Sarajevo Studentska 7 Fo\u010da Bosnia and Herzegovina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Kova\u010devi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy University of Belgrade\u2010Faculty of Pharmacy V.Stepe 450 Belgrade Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"246","volume-title":"Flora SR Srbije","author":"Nikoli\u0107 V.","year":"1973"},{"key":"e_1_2_6_3_1","unstructured":"I.Vu\u010dkovi\u0107 Ph.D. Thesis Univezitet u Beogradu Srbija 2011."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.03.015"},{"key":"e_1_2_6_5_1","first-page":"277","article-title":"Chemical Composition, Antimicrobial and Antioxidant Activities of Seseli pallasii \n                  Besser. 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