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In the current study, eight phenolic compounds, <jats:italic>e.g<\/jats:italic>., luteolin 5\u2010<jats:italic>O\u2010\u03b2<\/jats:italic>\u2010glucoside (<jats:bold>1<\/jats:bold>), methyl rosmarinate (<jats:bold>2<\/jats:bold>), apigenin (<jats:bold>3<\/jats:bold>), vicenin 2 (<jats:bold>4<\/jats:bold>), lithospermic acid (<jats:bold>5<\/jats:bold>), soyasaponin <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:bold>6<\/jats:bold>), rubiadin 3\u2010<jats:italic>O\u2010\u03b2<\/jats:italic>\u2010primeveroside (<jats:bold>7<\/jats:bold>), and 4\u2010(<jats:italic>\u03b2<\/jats:italic>\u2010<jats:sc>d<\/jats:sc>\u2010glucopyranosyloxy)benzyl 3,4\u2010dihydroxybenzoate (<jats:bold>8<\/jats:bold>), isolated from various plant species were tested at 0.2\u00a0m<jats:sc>m<\/jats:sc> against carbonic anhydrase\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>) and urease using microtiter assays. Urease inhibition rate for compounds <jats:bold>1<\/jats:bold>\u00a0\u2013\u00a0<jats:bold>8<\/jats:bold> ranged between 5.0\u00a0\u2013\u00a041.7%, while only compounds <jats:bold>1<\/jats:bold>,<jats:bold> 2<\/jats:bold>, and <jats:bold>4<\/jats:bold> showed a considerable inhibition over 50% against <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> with the <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> values of 73.5\u00a0\u00b1\u00a01.05, 39.5\u00a0\u00b1\u00a01.14, and 104.5\u00a0\u00b1\u00a02.50\u00a0\u03bc<jats:sc>m<\/jats:sc>, respectively, where <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> of the reference (acetazolamide) was 21.0\u00a0\u00b1\u00a00.12\u00a0\u03bc<jats:sc>m<\/jats:sc>. <jats:italic>In silico<\/jats:italic> experiments were also performed through two docking softwares (Autodock Vina and i\u2010<jats:styled-content style=\"fixed-case\">GEMDOCK<\/jats:styled-content>) in order to find out interactions between the compounds and <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. Actually, compounds <jats:bold>6<\/jats:bold> (30.0%) and <jats:bold>7<\/jats:bold> (42.0%) possessed a better binding capability toward the active site of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>. According to our results obtained in this study, among the phenolic compounds screened, particularly <jats:bold>1<\/jats:bold>,<jats:bold> 2<\/jats:bold>, and <jats:bold>4<\/jats:bold> appear to be the promising inhibitors of <jats:styled-content style=\"fixed-case\">CA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> and may be further investigated as possible leads for diuretic, anti\u2010glaucoma, and antiepileptic agents.<\/jats:p>","DOI":"10.1002\/cbdv.201700024","type":"journal-article","created":{"date-parts":[[2017,2,16]],"date-time":"2017-02-16T21:13:26Z","timestamp":1487279606000},"source":"Crossref","is-referenced-by-count":16,"title":["Carbonic Anhydrase and Urease Inhibitory Potential of Various Plant Phenolics Using <i>in\u00a0vitro<\/i> and <i>in silico<\/i> Methods"],"prefix":"10.1002","volume":"14","author":[{"given":"Abdur","family":"Rauf","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Swabi Anbar Khyber Pakhtunkhwa 23561 Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muslim","family":"Raza","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical Technology No. 15 East Road of North Third Ring Chao Yang District Beijing 100029 P. 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