{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:48:19Z","timestamp":1790293699172,"version":"4.1.0"},"reference-count":73,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,6,14]],"date-time":"2017-06-14T00:00:00Z","timestamp":1497398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100010739","name":"University of Camerino","doi-asserted-by":"crossref","award":["FAR 2014\/15"],"award-info":[{"award-number":["FAR 2014\/15"]}],"id":[{"id":"10.13039\/501100010739","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fondo di Ateneo per la Ricerca","award":["FPI000044"],"award-info":[{"award-number":["FPI000044"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:p><jats:italic>Eryngium campestre<\/jats:italic> and <jats:italic>E. amethystinum<\/jats:italic> are thorny herbs belonging to the Apiaceae family and spontaneously growing in stony pastures and dry meadows, preferentially on calcareous substrates. In the Mediterranean countries, these plants have been used as a food or traditional remedies to treat various ailments. In the present work, we have analyzed the chemical composition of the essential oils distilled from the aerial parts by <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">FID<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">GC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">MS<\/jats:styled-content>, and evaluated their cytotoxic effects on a panel of human cancer cells, namely A375 (human malignant melanoma), <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> 231 cells (human breast adenocarcinoma), and <jats:styled-content style=\"fixed-case\">HCT<\/jats:styled-content>116 cells (human colon carcinoma), by the <jats:styled-content style=\"fixed-case\">MTT<\/jats:styled-content> assay. Furthermore, the <jats:italic>Eryngium<\/jats:italic> essential oils were evaluated for antioxidant and acetylcholinesterase (<jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE) activities. The two essential oils were rich in sesquiterpene hydrocarbons, with germacrene D as the major compound, accompanied by <jats:italic>allo<\/jats:italic>\u2010aromadendrene, <jats:italic>\u03b2<\/jats:italic>\u2010elemene, spathulenol, and ledol. They turned out to be highly cytotoxic on the tumor cells, with <jats:italic><jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub> values (1.65 \u2013 5.32 and 1.57 \u2013 2.99 \u03bcg\/ml for <jats:italic>E. amethystinum<\/jats:italic> and <jats:italic>E. campestre<\/jats:italic>, respectively) comparable or close to those of the anticancer drug cisplatin. The <jats:italic>E. amethystinum<\/jats:italic> essential oil exhibited a moderate antioxidant activity, whereas that of <jats:italic>E. campestre<\/jats:italic> a weak <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE inhibition.<\/jats:p>","DOI":"10.1002\/cbdv.201700096","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:45:01Z","timestamp":1490337901000},"source":"Crossref","is-referenced-by-count":44,"title":["Cytotoxic Essential Oils from <i>Eryngium campestre<\/i> and <i>Eryngium amethystinum<\/i> (Apiaceae) Growing in Central Italy"],"prefix":"10.1002","volume":"14","author":[{"given":"Kevin","family":"Cianfaglione","sequence":"first","affiliation":[{"name":"Plant Diversity and Ecosystems Management Unit School of Biosciences and Veterinary Medicine University of Camerino Via Pontoni 5 IT\u201062032 Camerino"},{"name":"EA 2219 G\u00e9oarchitecture UFR Sciences &amp; Techniques Universit\u00e9 de Bretagne Occidentale 6 Avenue Victor Le Gorgeu FR\u201029200 Brest"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evy E.","family":"Blomme","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Laboratory for Translational Research in Obstructive Pulmonary Diseases Ghent University Hospital De Pintelaan 185 BE\u20109000 Ghent"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana","family":"Quassinti","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino Via Gentile III da Varano IT\u201062032 Camerino"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bramucci","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino Via Gentile III da Varano IT\u201062032 Camerino"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulio","family":"Lupidi","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino Via Gentile III da Varano IT\u201062032 Camerino"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Dall'Acqua","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padova Via Marzolo 5 IT\u201035131 Padova"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1375-4744","authenticated-orcid":false,"given":"Filippo","family":"Maggi","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of Camerino Via Sant'Agostino 1 IT\u201062032 Camerino"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,14]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"149","article-title":"Plant Essential Oils from Apiaceae Family as Alternatives to Conventional Insecticides","volume":"5","author":"Ebadollahi A.","year":"2013","journal-title":"Ecologia Balkanica"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2014.05.055"},{"key":"e_1_2_7_4_1","volume-title":"Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics","author":"Leung A. 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