{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:31:54Z","timestamp":1787502714742,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>\n                    The edible plants have long been reported to possess a lot of biological activities. Herein, the hepatoprotective and the antioxidant activities of the aqueous infusion of the edible parts of\n                    <jats:italic>Cynara cardunculus<\/jats:italic>\n                    ,\n                    <jats:italic>Ficus carica<\/jats:italic>\n                    , and\n                    <jats:italic>Morus nigra<\/jats:italic>\n                    and their herbal mixture (\n                    <jats:styled-content style=\"fixed-case\">CFM<\/jats:styled-content>\n                    ) was investigated\n                    <jats:italic>in\u00a0vitro<\/jats:italic>\n                    using\n                    <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                    l\n                    <jats:sub>4<\/jats:sub>\n                    induced damage in HepG2 cells. The highest amelioration was observed\n                    <jats:italic>via<\/jats:italic>\n                    the consumption of\n                    <jats:styled-content style=\"fixed-case\">CFM<\/jats:styled-content>\n                    at 1\u00a0mg\/ml showing 47.00% and 37.09% decline in aspartate transaminase and alanine transaminase and 77.32% and 101.02% increase in reduced glutathione and superoxide dismutase comparable to\n                    <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>\n                    l\n                    <jats:sub>4<\/jats:sub>\n                    treated cells. Metabolic profiling of their aqueous infusions was done using nuclear magnetic resonance spectroscopic experiments coupled with chemometrics particularly hierarchical cluster analysis (\n                    <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>\n                    ) and principal component analysis (\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    ). The structural closeness of the various metabolites existing in black berry and the mixture as reflected in the\n                    <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>\n                    score plot and\n                    <jats:styled-content style=\"fixed-case\">HCA<\/jats:styled-content>\n                    processed from the\n                    <jats:sup>1<\/jats:sup>\n                    H\u2010\n                    <jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content>\n                    spectral data could eventually explained the close values in their biological behavior. For fig and artichoke, the existence of different phenolic metabolites that act synergistically could greatly interpret their potent biological behavior. Thus, it can be concluded that a herbal mixture composed of black berry, artichoke, and fig could afford an excellent natural candidate to combat oxidative stress and counteract hepatic toxins owing to its phenolic compounds.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.201700206","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T12:26:08Z","timestamp":1505219168000},"source":"Crossref","is-referenced-by-count":37,"title":["Synergistic Hepatoprotective and Antioxidant Effect of Artichoke, Fig, Blackberry Herbal Mixture on HepG2 Cells and Their Metabolic Profiling Using\n                    <scp>NMR<\/scp>\n                    Coupled with Chemometrics"],"prefix":"10.1002","volume":"14","author":[{"given":"Fadia S.","family":"Youssef","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia Cairo 11566 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rola M.","family":"Labib","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia Cairo 11566 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omayma A.","family":"Eldahshan","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia Cairo 11566 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel Nasser B.","family":"Singab","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy Faculty of Pharmacy Ain Shams University Abbassia Cairo 11566 Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1489"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2016.08.006"},{"key":"e_1_2_7_5_1","first-page":"195","article-title":"Hepatoprotective Activity of Different Extracts of Brassica oleracea capitata Rubra Leaves (Red Cabbage) Against CCl4 Induced Hepatotoxicity in Rats","volume":"47","author":"Singab A.","year":"2009","journal-title":"Bull. 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