{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:11:51Z","timestamp":1790611911837,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,12,5]],"date-time":"2017-12-05T00:00:00Z","timestamp":1512432000000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:p>Thirty\u2010seven phytophenolics and their synthetic analogues were evaluated for activity against two protozoal pathogens, <jats:italic>Leishmania donovani<\/jats:italic> and <jats:italic>Plasmodium falciparum<\/jats:italic> (D6 and W2 clones), respectively. 4,6\u2010Dimethoxyaurone demonstrated the highest activity with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> values of 13.2 and 16.9 \u03bc<jats:sc>m<\/jats:sc> against <jats:italic>L. donovani<\/jats:italic> and <jats:italic>P. falciparum<\/jats:italic> (W2 clone), respectively, without undesired cytotoxicity against VERO cells. The moiety having two benzene rings was critical to maintain the antiprotozoal activities based on the observation that both coumaranones and chromones were inactive while other test compounds, including coumarans and aurones, remained active. There was no correlation between antiprotozoal activities and previously evaluated insect antifeedant activity against common cutworms (<jats:italic>Spodoptera litura<\/jats:italic>). Flavonoids, including aurones, pterocarpans, and lignan like dihydrobenzofurans, structural analogues of coumarans, are abundant in fruits and vegetables, so these phytophenolics may act as natural antiprotozoal agents in humans.<\/jats:p>","DOI":"10.1002\/cbdv.201700324","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T08:32:41Z","timestamp":1507537961000},"source":"Crossref","is-referenced-by-count":12,"title":["Antimalarial and Antileishmanial Activities of Phytophenolics and Their Synthetic Analogues"],"prefix":"10.1002","volume":"14","author":[{"given":"Masanori","family":"Morimoto","sequence":"first","affiliation":[{"name":"USDA\u2010ARS, Natural Products Utilization Research Unit Thad Cochran Center University MS 38677 USA"},{"name":"Department of Applied Chemistry Graduated School of Agriculture Kindai University 3327\u2010204 Nakamachi Nara City Nara 631\u20108505 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Cantrell","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS, Natural Products Utilization Research Unit Thad Cochran Center University MS 38677 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shabana","family":"Khan","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research School of Pharmacy University of Mississippi MS 38677 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babu L.","family":"Tekwani","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research School of Pharmacy University of Mississippi MS 38677 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen O.","family":"Duke","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS, Natural Products Utilization Research Unit Thad Cochran Center University MS 38677 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(02)00052-2"},{"key":"e_1_2_6_3_1","first-page":"214","article-title":"Allelochemicals in Plant and Their Applications for the Lead of Agrochemicals","volume":"39","author":"Morimoto M.","year":"2004","journal-title":"Regul. 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