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The use of natural products, specifically<jats:italic>Tagetes patula<\/jats:italic>, has been suggested as an alternative method of combatting this issue. Chemical analyses of the extracts of this species described in the literature report the presence of important classes of secondary metabolites such as thiophenes, flavonoids, alkaloids, and benzofurans, some of which were identified and isolated in this study. The aim of this work was to test the effect of the essential oil (<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>) and the ethanolic extract of the aerial parts (Tp<jats:sub>Et<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>OH<\/jats:sub><\/jats:styled-content>) of<jats:italic>T. patula<\/jats:italic>on eggs and larvae of<jats:italic>H. contortus<\/jats:italic>, through an egg hatch test (<jats:styled-content style=\"fixed-case\">EHT<\/jats:styled-content>) and a larval development test (<jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content>). In the<jats:styled-content style=\"fixed-case\">EHT<\/jats:styled-content>, the<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>showed 100% inhibition at 0.75 mg mL<jats:sup>\u22121<\/jats:sup>(<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub>= 0.0780 mg mL<jats:sup>\u22121<\/jats:sup>), and the Tp<jats:sub>Et<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>OH<\/jats:sub><\/jats:styled-content>showed 100% inhibition at 100 mg mL<jats:sup>\u22121<\/jats:sup>(<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub>= 12.8 mg mL<jats:sup>\u22121<\/jats:sup>). In the<jats:styled-content style=\"fixed-case\">LDT<\/jats:styled-content>, the<jats:styled-content style=\"fixed-case\">EO<\/jats:styled-content>showed 100% inhibition at 0.375 mg mL<jats:sup>\u22121<\/jats:sup>(<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub>= 0.0400 mg mL<jats:sup>\u22121<\/jats:sup>), and the Tp<jats:sub>Et<\/jats:sub><jats:styled-content style=\"fixed-case\"><jats:sub>OH<\/jats:sub><\/jats:styled-content>showed 100% inhibition at 1.56 mg mL<jats:sup>\u22121<\/jats:sup>(<jats:italic><jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content><\/jats:italic><jats:sub>50<\/jats:sub>= 0.340 mg mL<jats:sup>\u22121<\/jats:sup>). Compared to available literature data, the results presented here suggest that the crude extracts of<jats:italic>T. patula<\/jats:italic>have substantial potential for controlling this nematode by interrupting its life cycle and\/or preventing it from reaching the infective stage.<\/jats:p>","DOI":"10.1002\/cbdv.201700507","type":"journal-article","created":{"date-parts":[[2017,11,27]],"date-time":"2017-11-27T08:12:58Z","timestamp":1511770378000},"source":"Crossref","is-referenced-by-count":13,"title":["Chemical Composition and<i>In vitro<\/i>Anthelmintic Activity of Extracts of<i>Tagetes patula<\/i>Against a Multidrug\u2010Resistant Isolate of<i>Haemonchus contortus<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Fl\u00e1vio Augusto Sanches","family":"Politi","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry Institute of Chemistry UNESP \u2013 Univ Estadual Paulista Rua Professor Francisco Degni 55, Bairro Quitandinha CEP 14800\u2010060 Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amauri Alves","family":"Souza J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Institute of Chemistry UNESP \u2013 Univ Estadual Paulista Rua Professor Francisco Degni 55, Bairro Quitandinha CEP 14800\u2010060 Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela Regina","family":"Fantatto","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines School of Pharmaceutical Sciences UNESP \u2013 Univ Estadual Paulista Rodovia Araraquara\u2010Ja\u00fa Km 01 s\/n, Bairro Campos Ville CEP 14800\u2010903 Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemeire Cristina Linhari Rodrigues","family":"Pietro","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines School of Pharmaceutical Sciences UNESP \u2013 Univ Estadual Paulista Rodovia Araraquara\u2010Ja\u00fa Km 01 s\/n, Bairro Campos Ville CEP 14800\u2010903 Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldomiro","family":"Barioni J\u00fanior","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria Embrapa Pecu\u00e1ria Sudeste Rodovia Washington Luiz Km 234 s\/n, Fazenda Canchim CEP 13560\u2010970 S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Dias","family":"Rabelo","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria Embrapa Pecu\u00e1ria Sudeste Rodovia Washington Luiz Km 234 s\/n, Fazenda Canchim CEP 13560\u2010970 S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humberto Ribeiro","family":"Bizzo","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria Embrapa Agroind\u00fastria de Alimentos Avenida das Am\u00e9ricas 29501, Bairro Guaratiba CEP 23020\u2010470 Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina de Souza","family":"Chagas","sequence":"additional","affiliation":[{"name":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria Embrapa Pecu\u00e1ria Sudeste Rodovia Washington Luiz Km 234 s\/n, Fazenda Canchim CEP 13560\u2010970 S\u00e3o Carlos SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maysa","family":"Furlan","sequence":"additional","affiliation":[{"name":"Department of Organic Chemistry Institute of Chemistry UNESP \u2013 Univ Estadual Paulista Rua Professor Francisco Degni 55, Bairro Quitandinha CEP 14800\u2010060 Araraquara SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"http:\/\/www.fao.org\/faostat\/en\/#data\/QL; Accessed December 07 2017."},{"key":"e_1_2_7_3_1","volume-title":"Anu\u00e1rio da Pecu\u00e1ria Brasileira","year":"2008"},{"key":"e_1_2_7_4_1","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica Produ\u00e7\u00e3o da Pecu\u00e1ria Municipal vol. 37 Minist\u00e9rio do Planejamento Or\u00e7amento e Gest\u00e3o IBGE Rio de Janeiro 2009 1\u201355."},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1590\/S0102-09352000000500021","article-title":"Aspectos Epidemiol\u00f3gicos da Caprinocultura Cearense","volume":"52","author":"Pinheiro R. 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