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For instance, the activation of this nicotinic receptor subtype in resident macrophages inhibits the production of pro\u2010inflammatory cytokines, thereby attenuating local inflammatory responses, and may open a new window in the treatment of chronic inflammatory disease, such as Crohn's disease, rheumatoid arthritis, psoriasis, and asthma. In continuation of our ongoing research for the development of new cholinergic drug candidates, we selected the nicotine derivative<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>55, which was previously shown to exert anti\u2010inflammatory effects via nicotinic stimulation, as a suitable compound for lead optimization. Through the isosteric replacement of its 3,5\u2010disubstituted 4,5\u2010dihydroisoxazole core with a 1,4\u2010disubstituted 1,2,3\u2010triazole ring, we could rapidly generate a small library of<jats:styled-content style=\"fixed-case\">CAP<\/jats:styled-content>55\u2010related analogs via a one\u2010pot copper(I)\u2010catalyzed azide\u2010alkyne cycloaddition. Receptor binding assays at<jats:styled-content style=\"fixed-case\">nAChR<\/jats:styled-content>s led to the identification of two promising derivatives, compounds<jats:bold>4<\/jats:bold>and<jats:bold>10<\/jats:bold>, worthy of further pharmacological studies.<\/jats:p>","DOI":"10.1002\/cbdv.201800210","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T19:55:25Z","timestamp":1530215725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A Small Library of 1,2,3\u2010Triazole Analogs of<scp>CAP<\/scp>\u201055: Synthesis and Binding Affinity at Nicotinic Acetylcholine Receptors"],"prefix":"10.1002","volume":"15","author":[{"given":"Luca","family":"Rizzi","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Farmaceutiche Sezione di Chimica Farmaceutica \u2018Pietro Pratesi\u2019 Universit\u00e0 degli Studi di Milano Via L. 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