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A significant part of the title compounds showed considerable antibacterial activity against Gram\u2010positive species. The most potent compound against Gram\u2010positive bacteria was 2\u2010chloro derivative <jats:bold>7h<\/jats:bold> and the most potent derivative against Gram\u2010negative bacteria was 3\u2010chloro compound <jats:bold>7i<\/jats:bold>. <jats:italic>In\u00a0vitro<\/jats:italic> antibacterial evaluation of compound <jats:bold>7h<\/jats:bold> against clinically isolated bacteria methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MRSA<\/jats:styled-content>) and methicillin\u2010sensitive <jats:italic>Staphylococcus aureus<\/jats:italic> (<jats:styled-content style=\"fixed-case\">MSSA<\/jats:styled-content>) showed that this compound acted better than ciprofloxacin against the latter bacteria. Docking study of compound <jats:bold>7h<\/jats:bold> in the active site of <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>aureus <\/jats:italic><jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> gyrase revealed that this ciprofloxacin\u2010dithiocarbamate derivative interacted with the main components of the active site of the enzyme.<\/jats:p>","DOI":"10.1002\/cbdv.201800273","type":"journal-article","created":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T01:31:43Z","timestamp":1531963903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biology\u2010Oriented Drug Synthesis (<scp>BIODS<\/scp>) Approach towards Synthesis of Ciprofloxacin\u2010Dithiocarbamate Hybrids and Their Antibacterial Potential both <i>in Vitro<\/i> and <i>in Silico<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Ensieh Nasli","family":"Esfahani","sequence":"first","affiliation":[{"name":"Diabetes 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