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In this study, chemical and biological investigations were carried out on\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    strain 4205 isolated from the paddy soil, leading to the identification and characterization of 10 albocycline\u2010type macrolides, among which 4 compounds were new, namely albocyclines A\u2013D (\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>4<\/jats:bold>\n                    ). The structures of\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>10<\/jats:bold>\n                    were identified according to the 1D\u2010 and 2D\u2010NMR spectroscopic data. Furthermore, compounds\n                    <jats:bold>1<\/jats:bold>\n                    \u2013\n                    <jats:bold>10<\/jats:bold>\n                    were evaluated for antimicrobial activity. Compounds\n                    <jats:bold>5<\/jats:bold>\n                    \u2013\n                    <jats:bold>7<\/jats:bold>\n                    displayed antimicrobial activities against\n                    <jats:italic>Candidaalbicans<\/jats:italic>\n                    ATCC 90028 with the same MIC value of 10.0\u2005mg\/mL and the IC\n                    <jats:sub>50<\/jats:sub>\n                    values of 1.5, 1.0, and 1.0\u2005mg\/mL, respectively. Thus, the research on\n                    <jats:italic>Streptomyces<\/jats:italic>\n                    sp. is of vital significance for developing new antibiotic agents.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.201800344","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T06:23:58Z","timestamp":1540448638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Albocycline\u2010type Macrolides with Antibacterial Activities from\n                    <i>Streptomyces<\/i>\n                    sp. 4205"],"prefix":"10.1002","volume":"16","author":[{"given":"Cheng\u2010Zhen","family":"Gu","sequence":"first","affiliation":[{"name":"College of Life Science, Fujian Agriculture Forestry University  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng\u2010Hao","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Crop Science, Fujian Agriculture Forestry University  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"L\u00fc","sequence":"additional","affiliation":[{"name":"College of Life Science, Fujian Agriculture Forestry University  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Jun","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Yuan","family":"Song","sequence":"additional","affiliation":[{"name":"College of Crop Science, Fujian Agriculture Forestry University  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Esmail","family":"Abdalla\u2005Elzaki","sequence":"additional","affiliation":[{"name":"College of Crop Science, Fujian Agriculture Forestry University  Fuzhou 350002 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong\u2010Ren","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany Chinese Academy of Sciences  Kunming 650201 P. R. 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