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The structures of the new compounds were elucidated by the spectroscopic analysis and by comparison with reported data. The absolute configuration was determined by the optical rotation and ECD experiments. In an <jats:italic>in\u2005vitro<\/jats:italic> test, compounds <jats:bold>1<\/jats:bold>, <jats:bold>5<\/jats:bold> and <jats:bold>9<\/jats:bold> exhibited significant down\u2010regulating activity of osteoclast cell differentiation at 0.5 and 1\u2005\u03bc<jats:sc>m<\/jats:sc>. This is the first report of the fungus <jats:italic>X. feejeensis<\/jats:italic> from a marine sponge and of osteoclastogenesis inhibitory activity for the metabolites of these kinds.<\/jats:p>","DOI":"10.1002\/cbdv.201800358","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T12:58:22Z","timestamp":1539003502000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Osteoclastogenesis Inhibitory Polyketides from the Sponge\u2010Associated Fungus <i>Xylaria feejeensis<\/i>"],"prefix":"10.1002","volume":"15","author":[{"given":"Jie","family":"Wang","sequence":"first","affiliation":[{"name":"Institute of Tropical Agriculture and Forestry Hainan University  58 Renmin Avenue, Haikou 570228 P. R. China"},{"name":"Research Centers for Marine Drugs and Pharmaceutical Analysis, School of Pharmacy Second Military Medical University  325 Guo-He Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong\u2010Cong","family":"Xu","sequence":"additional","affiliation":[{"name":"Research Centers for Marine Drugs and Pharmaceutical Analysis, School of Pharmacy Second Military Medical University  325 Guo-He Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Tang","sequence":"additional","affiliation":[{"name":"Research Centers for Marine Drugs and Pharmaceutical Analysis, School of Pharmacy Second Military Medical University  325 Guo-He Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Su","sequence":"additional","affiliation":[{"name":"Research Centers for Marine Drugs and Pharmaceutical Analysis, School of Pharmacy Second Military Medical University  325 Guo-He Road Shanghai 200433 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalan","family":"Chou","sequence":"additional","affiliation":[{"name":"Department of Oceanography National Sun Yat-sen University, 70 Lien-Hai Road  Kaohsiung 80424 Taiwan, R. o. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keryea","family":"Soong","sequence":"additional","affiliation":[{"name":"Department of Oceanography National Sun Yat-sen University, 70 Lien-Hai Road  Kaohsiung 80424 Taiwan, R. o. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Research Centers for Marine Drugs and Pharmaceutical Analysis, School of Pharmacy Second Military Medical University  325 Guo-He Road Shanghai 200433 P. R. 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