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Biodiversity"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we evaluated the <jats:italic>in\u2005vitro<\/jats:italic> and <jats:italic>in\u2005vivo<\/jats:italic> schistosomicidal activities of chalcones against <jats:italic>Schistosoma mansoni<\/jats:italic> worms. <jats:italic>In vitro<\/jats:italic> assays revealed that chalcones <jats:bold>1<\/jats:bold> and <jats:bold>3<\/jats:bold> were the most active compounds, without affecting significantly mammalian cells. Confocal laser scanning microscopy and scanning electron microscopy studies revealed reduction on the numbers of tubercles and morphological alterations in the tegument of <jats:italic>S. mansoni<\/jats:italic> worms after <jats:italic>in\u2005vitro<\/jats:italic> incubation with chalcones <jats:bold>1<\/jats:bold> and <jats:bold>3<\/jats:bold>. In a mouse model of schistosomiasis, the oral treatment (400\u2005mg\/kg) with chalcone <jats:bold>1<\/jats:bold> or <jats:bold>3<\/jats:bold> significantly caused a total worm burden reduction in mice. Chalcone <jats:bold>1<\/jats:bold> showed significant inhibition of the <jats:italic>S. mansoni<\/jats:italic> ATP diphosphohydrolase activity, which was corroborated by molecular docking studies. The results suggested that chalcones could be explored as lead compounds with antischistosomal properties.<\/jats:p>","DOI":"10.1002\/cbdv.201800398","type":"journal-article","created":{"date-parts":[[2018,10,2]],"date-time":"2018-10-02T00:05:37Z","timestamp":1538438737000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<i>In Vitro<\/i> and <i>in Vivo<\/i> Antischistosomal Activities of Chalcones"],"prefix":"10.1002","volume":"15","author":[{"given":"Vin\u00edcius R. D.","family":"Pereira","sequence":"first","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento de Ci\u00eancias Farmac\u00eauticas Universidade Federal de Juiz de Fora, R. Jos\u00e9 Louren\u00e7o Kelmer s\/n, Campus Universit\u00e1rio  36036-900 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael J. Alves","family":"Junior","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento de Ci\u00eancias Farmac\u00eauticas Universidade Federal de Juiz de Fora, R. Jos\u00e9 Louren\u00e7o Kelmer s\/n, Campus Universit\u00e1rio  36036-900 Juiz de Fora, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia S.","family":"da\u2005Silveira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Juiz de Fora, Juiz de Fora, MG  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinaldo B.","family":"Geraldo","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Departamento de Ci\u00eancias Farmac\u00eauticas Universidade Federal de Juiz de Fora, R. 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