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(Asteraceae). All compounds were isolated for the first time from this species. Compound <jats:bold>2<\/jats:bold> was identified as a new epimer of a known caryophyllene derivative isolated previously from <jats:italic>P. dysenterica<\/jats:italic>. Their structures were established by spectroscopic means including NMR analysis (1D\u2010 and 2D\u2010NMR) and ESI\u2010TOF\u2010MS. All compounds were evaluated for their anticholinesterase, antityrosinase and cytotoxic activities against two human cell lines (A549 and HeLa). Results showed that compound <jats:bold>5<\/jats:bold> exhibited the highest cytotoxic effect against A549 and anticholinesterase activity with IC<jats:sub>50<\/jats:sub> values of 8.50\u00b10.75 and 6.45\u00b10.09\u2005\u03bcg\/mL, respectively. Furthermore, compound <jats:bold>5<\/jats:bold> showed also an interesting antityrosinase activity with percent inhibition value of 79.0\u00b12.5\u2009% at 50\u2005\u03bcg\/mL. The bioactivity and drug likeness scores of the isolated compounds <jats:bold>1\u20135<\/jats:bold> were calculated using Molinspiration software and discussed. These results may suggest that the five caryophyllene derivatives endowed with good biological properties, which could be used as bioactive alternatives in pharmaceutical preparations.<\/jats:p>","DOI":"10.1002\/cbdv.201800483","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T18:31:04Z","timestamp":1548354664000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Caryophyllene Sesquiterpenes from <i>Pulicaria vulgaris<\/i><scp>Gaertn<\/scp>.: Isolation, Structure Determination, Bioactivity and Structure\u2212Activity Relationship"],"prefix":"10.1002","volume":"16","author":[{"given":"Afifa","family":"Zardi\u2010Bergaoui","sequence":"first","affiliation":[{"name":"Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir University of Monastir, Avenue of Environment  5019 Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mansour","family":"Znati","sequence":"additional","affiliation":[{"name":"Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir University of Monastir, Avenue of Environment  5019 Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fethia","family":"Harzallah\u2010Skhiri","sequence":"additional","affiliation":[{"name":"Laboratory of Genetics Biodiversity and Valorization of Bioresources (LR11ES41), Higher Institute of Biotechnology of Monastir University of Monastir, Monastir, Rue Tahar Haddad  5000 Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hichem Ben","family":"Jannet","sequence":"additional","affiliation":[{"name":"Laboratory of Heterocyclic Chemistry, Natural Products and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Faculty of Science of Monastir University of Monastir, Avenue of Environment  5019 Monastir Tunisia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","unstructured":"L.-L. 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