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The synthesis focuses on a Mitsunobu alkylation reaction to construct the C\u2212N(9) bond between a chiral fluorinated side\u2010chain residue and 6\u2010 or 7\u2010modified guanine analogs. Prodrugs of FPMP\u20107\u2010deazaguanine were also synthesized by derivatization of the corresponding phosphonic acid functionality with (bis)diamyl aspartate amidate groups, leading to moderate activity against human immunodeficiency virus type 1 (HIV\u20101).<\/jats:p>","DOI":"10.1002\/cbdv.201800532","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T23:24:56Z","timestamp":1542324296000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and Anti\u2010HIV Activity of Guanine Modified Fluorinated Acyclic Nucleoside Phosphonate Derivatives"],"prefix":"10.1002","volume":"16","author":[{"given":"Min","family":"Luo","sequence":"first","affiliation":[{"name":"Medicinal Chemistry Rega Institute for Medical Research, KU Leuven, Herestraat 49  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Groaz","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Rega Institute for Medical Research, KU Leuven, Herestraat 49  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"De\u2005Jonghe","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Chemotherapy Rega Institute for Medical Research, KU Leuven  Herestraat 49 bus 1043 3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Chemotherapy Rega Institute for Medical Research, KU Leuven  Herestraat 49 bus 1043 3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3589-8503","authenticated-orcid":false,"given":"Piet","family":"Herdewijn","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Rega Institute for Medical Research, KU Leuven, Herestraat 49  3000 Leuven Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,23]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","unstructured":"E. 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