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All examined <jats:italic>Hypericum<\/jats:italic> extracts inhibited DNase I with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> below 800\u2005\u03bcg\/ml, whereby <jats:italic>H. perforatum<\/jats:italic> was the most potent (<jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub>=391.26\u00b168.40\u2005\u03bcg\/ml). Among the investigated <jats:italic>Hypericum<\/jats:italic> secondary metabolites, rutin inhibited bovine pancreatic DNase I in a non\u2010competitive manner with <jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub> value of 108.90\u00b19.73\u2005\u03bc<jats:sc>m<\/jats:sc>. DNase I inhibitory ability of rutin was further confirmed on DNase I in rat liver homogenate (<jats:italic>IC<\/jats:italic><jats:sub>50<\/jats:sub>=137.17\u00b116.65\u2005\u03bc<jats:sc>m<\/jats:sc>). Due to the involvement of DNase I in apoptotic processes the results of this study indicate the importance of frequent rutin and <jats:italic>H. perforatum<\/jats:italic> consumption in daily human nutrition. Rutin is a dietary component that can contribute to male infertility prevention by showing dual mechanism of sperm DNA protection, DNase I inhibition and antioxidant activity.<\/jats:p>","DOI":"10.1002\/cbdv.201900069","type":"journal-article","created":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T12:57:50Z","timestamp":1552913870000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Rutin as Deoxyribonuclease I Inhibitor"],"prefix":"10.1002","volume":"16","author":[{"given":"Ana","family":"Kolarevic","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Medicine University of Nis  Bulevar Dr Zorana Djindjica 81 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Pavlovic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Mathematics University of Nis  Visegradska 33 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Djordjevic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Mathematics University of Nis  Visegradska 33 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Lazarevic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medicine University of Nis  Bulevar Dr Zorana Djindjica 81 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasa","family":"Savic","sequence":"additional","affiliation":[{"name":"Faculty of Technology University of Nis  Bulevar Oslobodjenja 124 16000 Leskovac Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Kocic","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Faculty of Medicine University of Nis  Bulevar Dr Zorana Djindjica 81 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"Anderluh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Ljubljana  Askerceva cesta 7 1000 Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7724-0967","authenticated-orcid":false,"given":"Andrija","family":"Smelcerovic","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Medicine University of Nis  Bulevar Dr Zorana Djindjica 81 18000 Nis Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"crossref","unstructured":"Y. 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