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A feature to be pointed out is its (4<jats:italic>R<\/jats:italic>) configuration that was inferred from the NOE experiments (HSQC\u2010NOESY and NOESY) and X\u2010ray crystallography. <jats:italic>In vitro<\/jats:italic> evaluation of this rare diterpene acid against the chloroquine\u2010resistant strain <jats:italic>Plasmodium falciparum<\/jats:italic> W2 by the <jats:italic>Pf<\/jats:italic>LDH method showed it disclosed a low antiplasmodial activity and was not cytotoxic to HepG2 cells (CC<jats:sub>50<\/jats:sub> 862.6\u00b16.7\u2005\u03bc<jats:sc>m<\/jats:sc>) by the MTT assay. The unequivocal NMR signals assignments, the X\u2010ray crystallographic structure, the assessment to the bioactivities and the occurrence this diterpene in <jats:italic>X. sericea<\/jats:italic> are reported here for the first time.<\/jats:p>","DOI":"10.1002\/cbdv.201900141","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T16:36:37Z","timestamp":1557851797000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Comprehensive View on (\u2212)\u20107\u2010Oxo\u2010<i>ent<\/i>\u2010kaur\u201016\u2010en\u201019\u2010oic Acid, the Major Constituent of <i>Xylopia sericea<\/i> Leaves Extract: Complete NMR Assignments, X\u2010Ray Crystallographic Structure, <i>in Vitro<\/i> Antimalarial Activity and Cytotoxicity"],"prefix":"10.1002","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7759-9694","authenticated-orcid":false,"given":"Douglas","family":"Costa\u2005Gontijo","sequence":"first","affiliation":[{"name":"Departamento de Produtos Farmac\u00eauticos Faculdade de Farm\u00e1cia Universidade Federal de Minas Gerais  Av. 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