{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:08:37Z","timestamp":1770275317050,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T00:00:00Z","timestamp":1560384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several species from the Apocynaceae family, such as <jats:italic>Tabernanthe iboga<\/jats:italic>, <jats:italic>Voacanga africana<\/jats:italic>, and many <jats:italic>Tabernaemontana<\/jats:italic> species, produce ibogan type alkaloids, some of which present antiaddictive properties. In this study, we used gas chromatography\/mass spectrometry (GC\/MS) to examine the efficiency of methanol, acetone, ethyl acetate, dichloromethane, chloroform, and hydrochloric acid in extracting the antiaddictive compounds coronaridine, ibogamine, voacangine, and ibogaine (altogether the CIVI\u2010complex) from the root barks of <jats:italic>Tabernaemontana alba<\/jats:italic> and <jats:italic>Tabernaemontana arborea<\/jats:italic>. These Mexican species have recently shown great potential as alternative natural sources of the aforementioned substances. Methanol proved to be the most suitable solvent. Furthermore, the crude methanolic extracts could be engaged in a one\u2010step demethoxycarbonylation process that converted coronaridine and voacangine directly into its non\u2010carboxylic counterparts ibogamine and ibogaine, respectively, without the intermediacy of their carboxylic acids. The established protocol straightforwardly simplifies the alkaloid mixture from four to two majority compounds. In summary, our findings facilitate and improve both the qualitative and quantitative analysis of CIVI\u2010complex\u2010containing plant material, as well as outlining a viable method for the bulk production of these scientifically and pharmaceutically important substances from Mexican <jats:italic>Tabernaemontana<\/jats:italic> species.<\/jats:p>","DOI":"10.1002\/cbdv.201900175","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T18:31:21Z","timestamp":1558031481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extraction and Conversion Studies of the Antiaddictive Alkaloids Coronaridine, Ibogamine, Voacangine, and Ibogaine from Two Mexican <i>Tabernaemontana<\/i> Species (Apocynaceae)"],"prefix":"10.1002","volume":"16","author":[{"given":"Felix","family":"Krengel","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Biol\u00f3gicas Universidad Nacional Aut\u00f3noma de M\u00e9xico  Av. Universidad 3000, Delegaci\u00f3n Coyoac\u00e1n C. P. 04360, Ciudad Universitaria Ciudad de M\u00e9xico M\u00e9xico"},{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Av. Universidad 3000, Circuito Exterior S\/N, Delegaci\u00f3n Coyoac\u00e1n C. P. 04510, Ciudad Universitaria Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco V.","family":"Mijangos","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Av. Universidad 3000, Circuito Exterior S\/N, Delegaci\u00f3n Coyoac\u00e1n C. P. 04510, Ciudad Universitaria Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisol","family":"Reyes\u2010Lezama","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM)  Av. 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