{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T16:37:03Z","timestamp":1781887023740,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to evaluate the chemical composition, and the trypanocidal and antibacterial activities of the essential oils from four species of Annonaceae: <jats:italic>Bocageopsis multiflora<\/jats:italic> (<jats:sc>Mart<\/jats:sc>.) R.E.<jats:sc>Fr<\/jats:sc>., <jats:italic>Duguetia quitarensis<\/jats:italic> <jats:sc>Benth<\/jats:sc>., <jats:italic>Fusaea longifolia<\/jats:italic> (<jats:sc>Aubl.<\/jats:sc>) <jats:sc>Saff<\/jats:sc>., and <jats:italic>Guatteria punctata<\/jats:italic> (<jats:sc>Aubl<\/jats:sc>.) R.A.<jats:sc>Howard<\/jats:sc>. The chemical composition of the essential oils from the aerial parts yielded 23, 20, 21 and 23 constituents, respectively, which were identified by GC\/MS. The trypanocidal activity was evaluated against the amastigote and trypomastigote forms of <jats:italic>T. cruzi<\/jats:italic>. The antibacterial activity was evaluated by the microdilution method against enterohemorrhagic <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Pseudomonas aeruginosa<\/jats:italic>, <jats:italic>Streptococcus mutans<\/jats:italic>, <jats:italic>Streptococcus pyogenes<\/jats:italic>, and methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>. The results of trypanocidal activity showed that the essential oils of the four species were active at the tested concentrations, with <jats:italic>G. punctata<\/jats:italic> essential oil being the most active, with IC<jats:sub>50<\/jats:sub>=0.029\u2005\u03bcg\/mL, and selectivity index (SI)=32, being 34 times more active than the reference drug benznidazole. All EOs showed strong antibacterial activity (minimum inhibitory concentrations of 4.68\u201337.5\u2005\u03bcg\/mL) against strains of <jats:italic>S. mutans<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/cbdv.201900359","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T02:05:13Z","timestamp":1569204313000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["<i>In Vitro<\/i> Trypanocidal and Antibacterial Activities of Essential Oils from Four Species of the Family Annonaceae"],"prefix":"10.1002","volume":"16","author":[{"given":"Marcia","family":"Bay","sequence":"first","affiliation":[{"name":"Federal Institute of Education Science and Technology of Rond\u00f4nia  CEP 76820-441 Porto Velho\/RO Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Vitor","family":"Souza de Oliveira","sequence":"additional","affiliation":[{"name":"Federal Institute of Education Science and Technology of Rond\u00f4nia  CEP 76820-441 Porto Velho\/RO Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Policarpo Ademar","family":"Sales Junior","sequence":"additional","affiliation":[{"name":"Ren\u00e9 Rachou Institute, FIOCRUZ Laboratory of Cellular and Molecular Parasitology  CEP 30190-002 Belo Horizonte\/MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvane Maria","family":"Fonseca Murta","sequence":"additional","affiliation":[{"name":"Ren\u00e9 Rachou Institute, FIOCRUZ Laboratory of Cellular and Molecular Parasitology  CEP 30190-002 Belo Horizonte\/MG Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson","family":"Rog\u00e9rio dos Santos","sequence":"additional","affiliation":[{"name":"Federal University of Paran\u00e1 Department of Chemistry, Polytechnic Center  CEP 81531-980 Curitiba\/PR Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivanildes","family":"dos Santos Bastos","sequence":"additional","affiliation":[{"name":"Biodiversity Coordination in Health Le\u00f4nidas &amp; Maria Deane Institute, Funda\u00e7\u00e3o Oswaldo Cruz  CEP 69057-070 Manaus\/AM Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia","family":"Puccinelli Orlandi","sequence":"additional","affiliation":[{"name":"Biodiversity Coordination in Health Le\u00f4nidas &amp; Maria Deane Institute, Funda\u00e7\u00e3o Oswaldo Cruz  CEP 69057-070 Manaus\/AM Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo","family":"Teixeira de Sousa Junior","sequence":"additional","affiliation":[{"name":"Federal University of Mato Grosso Institute of Exact and Earth Sciences, Department of Chemistry  CEP 78060-900 Cuiab\u00e1\/MT Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Health Organization\u2013Guia para Vigil\u00e2ncia Preven\u00e7\u00e3o Controle e Manejo Cl\u00ednico da Doen\u00e7a de Chagas Aguda Transmitida por Alimentos Geneva Organiza\u00e7\u00e3o Pan-Americana de Sa\u00fade 2009."},{"key":"e_1_2_7_2_1","first-page":"7","article-title":"\u2018II Consenso Brasileiro em Doen\u00e7a de Chagas\u2019","volume":"25","author":"Dias J. C. P.","year":"2016","journal-title":"Epidemiol. Serv. Sa\u00fade"},{"key":"e_1_2_7_3_1","first-page":"e00006517","article-title":"\u2018Investiga\u00e7\u00e3o de Surto de Doen\u00e7a de Chagas Aguda na Regi\u00e3o Extra-Amaz\u00f4nica\u2019","volume":"34","author":"Vargas A.","year":"2018","journal-title":"Cad. Sa\u00fade P\u00fabl."},{"key":"e_1_2_7_4_1","first-page":"345","article-title":"\u2018Avalia\u00e7\u00e3o do Conhecimento Acerca do Manejo Cl\u00ednico de Portadores da Doen\u00e7a de Chagas em Regi\u00e3o End\u00eamica no Brasil\u2019","volume":"21","author":"Ferreira A. M.","year":"2018","journal-title":"Rev. APS"},{"key":"e_1_2_7_5_1","unstructured":"Conitec\u2013Comiss\u00e3o Nacional de Incorpora\u00e7\u00e3o de Tecnologias no Sistema \u00danico de Sa\u00fade\u2013Protocolo Cl\u00ednico e Diretrizes Terap\u00eauticas Doen\u00e7a de Chagas Relat\u00f3rio de Recomenda\u00e7\u00e3o Bras\u00edlia. Minist\u00e9rio da Sa\u00fade 2018"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiph.2017.02.010"},{"key":"e_1_2_7_7_1","first-page":"77","article-title":"\u2018O Uso de Antibi\u00f3ticos e as Resist\u00eancias Bacterianas: Breves Notas Sobre a sua Evolu\u00e7\u00e3o\u2019","volume":"34","author":"Loureiro R. J.","year":"2016","journal-title":"Rev. Port. Sa\u00fade P\u00fabl."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2013.840809"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2015.01.003"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules170911056"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2015.1015017"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700097"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2016.1210041"},{"key":"e_1_2_7_14_1","first-page":"619","article-title":"\u2018Chemical Composition and Bactericidal Activity of the Essential Oils of Four Species of Annonaceae Growing in Brazilian Amazon\u2019","volume":"12","author":"Alcantara J. M.","year":"2017","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_15_1","first-page":"4050","article-title":"\u2018Influ\u00eancia dos Fatores Abi\u00f3ticos na Composi\u00e7\u00e3o Qu\u00edmica dos \u00d3leos Essenciais\u2019","volume":"27","author":"Morais L. A. S.","year":"2009","journal-title":"Hortic. Bras."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2005000200008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-695X2008000300011"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2010.9700323"},{"key":"e_1_2_7_19_1","doi-asserted-by":"crossref","unstructured":"J.\u2005E. do\u2005N.\u2005Fontes R.\u2005P.\u2005C. Ferraz A.\u2005C.\u2005S. Britto A.\u2005A. Carvalho M.\u2005O. Moraes C. Pessoa E.\u2005V. Costa D.\u2005P. Bezerra \u2018Antitumor Effect of the Essential Oil from Leaves ofGuatteria pogonopus(Annonaceae)\u2019 Chem. Biodiversity2013 10 722\u2013729.","DOI":"10.1002\/cbdv.201200304"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1163691"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2014.982876"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","unstructured":"R.\u2005P.\u2005C. Ferraz G.\u2005M.\u2005B. Cardoso T.\u2005B. da\u2005Silva J.\u2005E. do\u2005N.\u2005Fontes A.\u2005P. do\u2005N.\u2005Prata A.\u2005A. Carvalho M.\u2005O. Moraes C. Pessoa E.\u2005V. Costa D.\u2005P. Bezerra \u2018Antitumor properties of the Leaf Essential Oil ofXylopia frutescensAubl. (Annonaceae)\u2019 Food Chem.2013 141 196\u2013200.","DOI":"10.1016\/j.foodchem.2013.02.114"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762010000200022"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13420"},{"key":"e_1_2_7_25_1","first-page":"403","article-title":"\u2018Chemical Composition and anti-Trypanosoma cruzi Activity of Essential Oils obtained from Leaves of Xylopia frutescens and Xylopia laevigata (Annonaceae)\u2019","volume":"8","author":"Silva T. B.","year":"2013","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf001494m"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2741\/1305"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","unstructured":"T.\u2005L. Lamagni J. Darenberg B. Luca-Harari T. Siljander A. Efstratiou B. Henriques-Normak J. Vuopio-Varkila A. Bouvet R. Creti K. Ekelund M. Koliou R.\u2005R. Reinert A. Stathi L. Strakova V. Ungureanu C. Shal\u00e9n the Strep-EURO Study Group A. Jasir \u2018Epidemiology of SevereStreptococcus pyogenesDisease in Europe\u2019 J. Clin. Microbiol.2008 7 2359\u20132367.","DOI":"10.1128\/JCM.00422-08"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233713498458"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-66902012000200025"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v34i0.1667"},{"key":"e_1_2_7_32_1","unstructured":"R.\u2005P. Adams \u2018Identification of Essential Oil Components by Gas Chromatography\/Mass Spectrometry\u2019 Allured Publishing Corporation Illinois 2007."},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.11.2592"},{"key":"e_1_2_7_34_1","unstructured":"Clinical and Laboratory Standards Institute (CLSI) Approved Standard M07-A9 Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Ninth Edition Wayne Clinical and Laboratory Standarts Institute 2012."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201900359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201900359","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.201900359","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201900359","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T12:18:10Z","timestamp":1694175490000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201900359"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/cbdv.201900359"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201900359","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]},"assertion":[{"value":"2019-06-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1900359"}}