{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:34:15Z","timestamp":1786977255799,"version":"build-2736575974"},"reference-count":47,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T00:00:00Z","timestamp":1571616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660626"],"award-info":[{"award-number":["81660626"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The frequent disease of\n                    <jats:italic>Panax notoginseng<\/jats:italic>\n                    caused by the pathogenic fungi in field cultivation has become the major threaten to the sustainable development of it. The present study was conducted to find natural agent with potential inhibition against pathogen. Therefore, the inhibitory effects of\n                    <jats:italic>Cinnamomum cassia<\/jats:italic>\n                    (L.) J.\n                    <jats:sc>Presl<\/jats:sc>\n                    essential oils (EOs) against\n                    <jats:italic>P. notoginseng<\/jats:italic>\n                    associated pathogenic fungi were conducted both\n                    <jats:italic>in\u2005vitro<\/jats:italic>\n                    and\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    experiments. The results of the Oxford cup test revealed that\n                    <jats:italic>C. cassia<\/jats:italic>\n                    dry bark EO (50\u2005mg\/mL) had significant inhibitory activity on the growth of all tested fungi, and the growth of various pathogens was completely inhibited, except for that of\n                    <jats:italic>Fusarium solani<\/jats:italic>\n                    . Therefore, the constituents of\n                    <jats:italic>C. cassia<\/jats:italic>\n                    EOs were analyzed by GC\/MS, and the research demonstrated that the main constituents of\n                    <jats:italic>C. cassia<\/jats:italic>\n                    dry bark EO were\n                    <jats:italic>trans<\/jats:italic>\n                    \u2010cinnamaldehyde (75.65\u2009%), (\n                    <jats:italic>E<\/jats:italic>\n                    )\u20102\u2010methoxycinnamaldehyde (6.08\u2009%), cinnamaldehyde (3.47\u2009%) and cinnamyl acetate (1.02\u2009%). The MIC results showed that\n                    <jats:italic>C. cassia<\/jats:italic>\n                    dry bark EO and the main compounds had good antifungal effect on the tested strains, and the inhibitory effect was similar to that of hymexazol (chemical pesticide). By analyzing the value of the fraction inhibitory concentration index (FICI), additive effects, irrelevant effects and synergistic effects were observed after the mixture of hymexazol against various pathogens. Moreover,\n                    <jats:italic>in\u2005vivo<\/jats:italic>\n                    model showed that\n                    <jats:italic>C. cassia<\/jats:italic>\n                    dry bark EO could reduce the occurrence of anthrax in\n                    <jats:italic>P. notoginseng<\/jats:italic>\n                    . To widen the resources of\n                    <jats:italic>C. cassia<\/jats:italic>\n                    available, the compositions of both\n                    <jats:italic>C. cassia<\/jats:italic>\n                    fresh bark and leaf EOs were also tested and many common compositions existed among them. Taken together, it was concluded that\n                    <jats:italic>C. cassia<\/jats:italic>\n                    EO had the potential use in the field to reduce the pathogenic disease.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.201900416","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T03:37:53Z","timestamp":1571629073000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Fungicidal Activity of Essential Oils from\n                    <i>Cinnamomum cassia<\/i>\n                    against the Pathogenic Fungi of\n                    <i>Panax notoginseng<\/i>\n                    Diseases"],"prefix":"10.1002","volume":"16","author":[{"given":"Yu\u2010Nan","family":"Ma","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Yunnan University of Chinese Medicine  Kunming 650500 P. R. 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