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Tyrosine kinase inhibitors (TKIs) are used to treat CML patients, but these have limited efficacy due to the emergence of resistance via genetic mutation. Kamebakaurin is an <jats:italic>ent<\/jats:italic>\u2010kaurane diterpenoid that has been isolated from <jats:italic>Rabdosia excisa<\/jats:italic> (<jats:sc>Maxim<\/jats:sc>.) H.<jats:sc>Hara<\/jats:sc>. Herein, we investigate the potential of kamebakaurin as a chemotherapy reagent for the treatment of CML. We conducted <jats:italic>in\u2005vitro<\/jats:italic> and <jats:italic>in\u2005vivo<\/jats:italic> biological experiments and found that kamebakaurin potently inhibits cell proliferation, mainly by enhancing cell apoptosis and down\u2010regulating Bcr\u2010Abl protein levels. In addition, kamebakaurin was found to inhibit tumor growth and has no side effects on five internal organs for <jats:italic>in\u2005vivo<\/jats:italic> experiment. These results suggest that kamebakaurin is a potential anticancer agent and is a key compound for further investigations.<\/jats:p>","DOI":"10.1002\/cbdv.201900443","type":"journal-article","created":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T02:41:21Z","timestamp":1567132881000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An <i>ent<\/i>\u2010Kaurane Diterpenoid Isolated from <i>Rabdosia excisa<\/i> Suppresses Bcr\u2010Abl Protein Expression <i>in Vitro<\/i> and <i>in Vivo<\/i> and Induces Apoptosis of CML Cells"],"prefix":"10.1002","volume":"16","author":[{"given":"Yan","family":"Xia","sequence":"first","affiliation":[{"name":"College of Chemistry and Life Science Changchun University of Technology  Changchun 130012 P. R. China"},{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"Advanced Institute of Materials Science Changchun University of Technology  Changchun 130012 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miao","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science Changchun University of Technology  Changchun 130012 P. R. China"},{"name":"Advanced Institute of Materials Science Changchun University of Technology  Changchun 130012 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erkang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun 130022 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Advanced Institute of Materials Science Changchun University of Technology  Changchun 130012 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"Department of Chemistry and Physics State University of New York at Stony Brook  New York 11790 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6764-3308","authenticated-orcid":false,"given":"Ruibin","family":"Hou","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science Changchun University of Technology  Changchun 130012 P. R. China"},{"name":"Advanced Institute of Materials Science Changchun University of Technology  Changchun 130012 P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinping","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Chemistry and Life Science Changchun University of Technology  Changchun 130012 P. R. China"},{"name":"State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry, Chinese Academy of Sciences  Changchun 130022 P. R. China"},{"name":"Advanced Institute of Materials Science Changchun University of Technology  Changchun 130012 P. R. 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