{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T01:31:59Z","timestamp":1782264719086,"version":"3.54.5"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Henan Natural Science Foundation of China","award":["162300410041"],"award-info":[{"award-number":["162300410041"]}]},{"name":"Training Program for Young Key Teachers in University of Henan Province","award":["2016GGjs-031"],"award-info":[{"award-number":["2016GGjs-031"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Veratrum<\/jats:italic> plant contains a family of compounds called steroidal alkaloids which have been previously reported to cause DNA damage and blood pressure decrease <jats:italic>in\u2005vivo<\/jats:italic>. In this study, the antihypertensive effects and DNA damage in brain cells of 12 steroidal alkaloids separated from <jats:italic>Veratrum<\/jats:italic> plant were all evaluated to develop a relationship among chemical structure, antihypertensive activity and neurotoxicity by utilization of chemical principal component analysis (PCA) and hierarchical cluster analysis (HCA). Twelve steroidal alkaloids markedly reduced high blood pressure of hypertensive mice and also similarly induced varying degrees of DNA single\u2010strand breaks in mouse cerebellum and cerebral cortex after oral administration. On the basis of the PCA and HCA results, it was suggested that the 3\u2010carboxylic esters and benzene group play a core role in the DNA damage of brain cells, while more hydroxy groups in the A\u2010ring and B\u2010ring structure of jervine\u2010type alkaloid led to stronger antihypertensive activity. The primary structure, activity and neurotoxicity relationship were discussed briefly.<\/jats:p>","DOI":"10.1002\/cbdv.201900473","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T13:45:22Z","timestamp":1579614322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A Structure\u2010Activity Relationship between the <i>Veratrum<\/i> Alkaloids on the Antihypertension and DNA Damage Activity in Mice"],"prefix":"10.1002","volume":"17","author":[{"given":"Yue","family":"Cong","sequence":"first","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical College Henan University  Kaifeng 475004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yantong","family":"Wu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy, Pharmaceutical College Henan University  Kaifeng 475004 P. R. 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