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Lipophilic DHF produced important antibacterial synergistic effects in association with ciprofloxacin (CPX) against two biofilm\u2010forming strains of <jats:italic>S. aureus<\/jats:italic> HT1 (FIC=0.21) and <jats:italic>P. aeruginosa<\/jats:italic> HT5 (FIC=0.05). Hence, this mixture constitutes an excellent strategy to combat these biofilm\u2010producing bacteria that overexpress drug efflux pumps as a resistance mechanism. Additionally, a substantial rise in beneficial <jats:italic>Lactobacillus<\/jats:italic> biofilm biomass was determined as a very significant finding of this association. Particularly, a non\u2010pathogenic biofilm increment of 119\u2009% was quantified when the mixture was added to a probiotic <jats:italic>L. acidophilus<\/jats:italic> ATCC SD\u20105212 culture. A surface activity enhanced in 71\u2009% with respect to untreated <jats:italic>L. acidophilus<\/jats:italic> culture was also generated by the DHF and CPX association, and therefore, a glycoprotein synthesis induction mediated by the mixture is discussed. The results obtained could help in the development of new selective antibiotics. From an ecological standpoint, the present study strongly suggests that DHF is a polyfunctional organic molecule produced with a high yield in <jats:italic>Senecio punae<\/jats:italic> that exerts a positive impact on a non\u2010pathogenic plant bacterium <jats:italic>L. plantarum<\/jats:italic> CE105.<\/jats:p>","DOI":"10.1002\/cbdv.201900507","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T01:55:29Z","timestamp":1586570129000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Lipophilic 9,10\u2010Dehydrofukinone Action on Pathogenic and Non\u2010Pathogenic Bacterial Biofilms. Why Is This Main Volatile Metabolite in <i>Senecio<\/i>?"],"prefix":"10.1002","volume":"17","author":[{"given":"Mar\u00eda C.","family":"Verni","sequence":"first","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"},{"name":"INBIOFAL (CONICET-UNT)  Av. Kirchner 1900 Tucum\u00e1n 4000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 A.","family":"Garay","sequence":"additional","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"Bard\u00f3n","sequence":"additional","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Borkosky","sequence":"additional","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario E.","family":"Arena","sequence":"additional","affiliation":[{"name":"Facultad de Bioqu\u00edmica Qu\u00edmica y Farmacia Universidad Nacional de Tucum\u00e1n  Ayacucho 471 Tucum\u00e1n 4000 Argentina"},{"name":"INBIOFAL (CONICET-UNT)  Av. 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