{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T14:45:24Z","timestamp":1791557124554,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81660641"],"award-info":[{"award-number":["81660641"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Coreopsis tinctoria<\/jats:italic> capitula (CTC) of the Compositae family has been used traditionally to treat various diseases in China, particularly type 2 diabetes mellitus (T2DM). This study evaluated the anti\u2010lipid peroxidation, <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase and <jats:italic>\u03b1<\/jats:italic>\u2010amylase inhibitory effects of CTC extracts, and analyzed its chemical composition by HPLC. Moreover, the antioxidant activity and protection effects of CTC extracts were investigated on high\u2010fat\/high\u2010sugar and streptozotocin\u2010induced T2DM mice. In vitro study, the ethyl acetate extract (EAE) and butanol extract (BE) of CTC exhibited anti\u2010lipid peroxidation (IC<jats:sub>50<\/jats:sub>: BHA&gt;BE or EAE&gt;ascorbic acid, <jats:italic>p<\/jats:italic>&lt;0.05) and <jats:italic>\u03b1<\/jats:italic>\u2010glucosidase inhibitory activity (IC<jats:sub>50<\/jats:sub>: BE&gt;EAE, <jats:italic>p<\/jats:italic>&lt;0.05). In vivo, the BE at the dose of 600\u2005mg\/kg was intragastrically given to T2DM mice, which exhibited a certain extent of repair and improvement of the levels of CAT, GSH, GSH\u2010P<jats:sub>X<\/jats:sub>, SOD, as well as plasma biomarkers, compared with those in the model group (<jats:italic>p<\/jats:italic>&lt;0.05). These results demonstrated that CTC extracts have a positive effect to treat T2DM and it can be used for the treatment of T2DM in the future.<\/jats:p>","DOI":"10.1002\/cbdv.201900514","type":"journal-article","created":{"date-parts":[[2019,10,14]],"date-time":"2019-10-14T12:07:32Z","timestamp":1571054852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti\u2010Lipid Peroxidation, <i>\u03b1<\/i>\u2010Glucosidase and <i>\u03b1<\/i>\u2010Amylase Inhibitory Effects of the Extract of Capitula of <i>Coreopsis tinctoria<\/i><scp>N<\/scp>utt. and Protection Effects on High\u2010Fat\/High\u2010Sugar and Streptozotocin\u2010Induced Type 2 Diabetes in Mice"],"prefix":"10.1002","volume":"16","author":[{"given":"Yushan","family":"Zhang","sequence":"first","affiliation":[{"name":"School of Pharmacy Shihezi University  North 4 Road Shihezi 832000 P. R. 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