{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T05:07:39Z","timestamp":1792040859491,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2017YFC1703900"],"award-info":[{"award-number":["2017YFC1703900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Brassica rapa<\/jats:italic>\n                    L., also called NIUMA, is used empirically in Tibetan medicine for its antioxidant, anti\u2010inflammatory and antiradiation activities. This study explored the hepatoprotective effects of\n                    <jats:italic>B. rapa<\/jats:italic>\n                    polysaccharides (BRPs) on acute liver injury induced by carbon tetrachloride (CCl\n                    <jats:sub>4<\/jats:sub>\n                    ) in mice and the underlying mechanisms. Mice were treated with CCl\n                    <jats:sub>4<\/jats:sub>\n                    after the oral administration of BRPs (55, 110 and 220\u2005mg\/kg) or bifendate (100\u2005mg\/kg) for 7\u2005days. Blood and liver samples of mice were collected for analysis after 24\u2005h. The ALP, ALT and AST levels and the biological activities of SOD, MDA and GSH\u2212Px were measured. Histopathological changes in the liver were determined through hematoxylin and eosin staining. Moreover, TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and IL\u20106 expression levels were detected by commercial reagent kits. Finally, Western blot analysis was used to check the relative expression levels of caspase\u20103,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010JAK2 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2010STAT3. The BRP pre\u2010treatment significantly decreased the enzymatic activities of ALT, ALP and AST in the serum, markedly increased the activities of SOD and GSH\u2212Px in the liver and reduced the MDA concentration in the liver. BRPs alleviated hepatocyte injury and markedly inhibited the expression of TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    , IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    and IL\u20106, also downregulating the CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced hepatic tissue expression of caspase\u20103. Furthermore, BRPs inhibited the JAK2\/STAT3 signaling pathway in a dose\u2010dependent manner in the liver. This study demonstrated that BRPs exert hepatoprotective effect against the CCl\n                    <jats:sub>4<\/jats:sub>\n                    \u2010induced liver injury via modulating the apoptotic and inflammatory responses and downregulating the JAK2\/STAT3 signaling pathway. Therefore,\n                    <jats:italic>B. rapa<\/jats:italic>\n                    could be considered a hepatoprotective medicine.\n                  <\/jats:p>","DOI":"10.1002\/cbdv.201900534","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T12:50:19Z","timestamp":1573822219000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["<i>Brassica rapa<\/i>\n                    Polysaccharides Ameliorate CCl\n                    <sub>4<\/sub>\n                    \u2010Induced Acute Liver Injury in Mice through Inhibiting Inflammatory Apoptotic Response and Oxidative Stress"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0058-503X","authenticated-orcid":false,"given":"Qiuyue","family":"Li","sequence":"first","affiliation":[{"name":"School of Ethnic Medicine Chengdu University of Traditional Chinese Medicine  Chengdu 610075 P. R. 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