{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:41:08Z","timestamp":1790430068118,"version":"4.1.0"},"reference-count":86,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,9]],"date-time":"2020-04-09T00:00:00Z","timestamp":1586390400000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Rhus coriaria<\/jats:italic> L. (Anacardiaceae), sumac, is a common condiment, appetizer and souring agent in the Mediterranean region that has a long history in traditional medicine. <jats:italic>R. coriaria<\/jats:italic> has been prescribed for the treatment of many ailments including diarrhea, ulcer, hemorrhoids, hemorrhage, wound healing, hematemesis, and eye ailments like ophthalmia and conjunctivitis. The plant is also used as diuresis, antimicrobial, abortifacient and as a stomach tonic. Sumac is known to be rich in different classes of phytochemicals including tannins, polyphenols, flavonoids, organic acids and essential oils and continues to be a hot topic for extensive research work designed for revealing its phytochemical constituents and evaluating its bioactive properties. This review summarizes the recent phytochemical and diverse bioactivity studies on <jats:italic>R. coriaria<\/jats:italic>, especially those concerned with antitumor, antioxidant, hypoglycemic, antimicrobial, and anti\u2010inflammatory studies.<\/jats:p>","DOI":"10.1002\/cbdv.201900561","type":"journal-article","created":{"date-parts":[[2020,3,6]],"date-time":"2020-03-06T12:04:30Z","timestamp":1583496270000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Phytochemical Diversity and Pharmacological Properties of <i>Rhus coriaria<\/i>"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9927-2214","authenticated-orcid":false,"given":"Zaha A.","family":"Elagbar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy P.O. Box 263 Al-Ahliyya Amman University  19328 Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2387-6940","authenticated-orcid":false,"given":"Ashok K.","family":"Shakya","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Faculty of Pharmacy P.O. Box 263 Al-Ahliyya Amman University  19328 Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9183-6855","authenticated-orcid":false,"given":"Lina M.","family":"Barhoumi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Al-Balqa Applied University  19117 Al-Salt Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5665-057X","authenticated-orcid":false,"given":"Hala I.","family":"Al\u2010Jaber","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Al-Balqa Applied University  19117 Al-Salt Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11130-007-0058-4"},{"key":"e_1_2_7_2_1","first-page":"933","article-title":"\u2018The effect of sumac (Rhus coriaria L.) powder on insulin resistance, malondialdehyde, high sensitive C-reactive protein and paraoxonase 1 activity in type 2 diabetic patients\u2019","volume":"19","author":"Rahideh S. T.","year":"2014","journal-title":"J. Res. Med. Sci."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.21767\/2576-1412.100021"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(01)00244-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(94)90102-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodcont.2010.06.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.10.086"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.942867"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.3215"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2009.10.051"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2003.09.043"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2008.10.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.5713\/ajas.18.0045"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50036a037"},{"key":"e_1_2_7_15_1","first-page":"1090","article-title":"\u2018Phytochemical profiling, antioxidant and antibacterial activities of leaf extracts from Rhus leptodictya\u2019","volume":"9","author":"Mtunzi F. M.","year":"2017","journal-title":"Int. J. Pharmacogn. Phytochem. Res."},{"key":"e_1_2_7_16_1","first-page":"1279","article-title":"\u2018A novel biflavonoid from Rhus leptodictya\u2019","volume":"11","author":"Matamela T.","year":"2016","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2004.09.003"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.01.021"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00217-019-03374-1"},{"key":"e_1_2_7_20_1","first-page":"505","article-title":"\u2018Rhus coriaria Linn., a plant of medicinal, nutritional and industrial importance: A review\u2019","volume":"22","author":"Shabbir A.","year":"2012","journal-title":"J. Anim. Plant Sci."},{"key":"e_1_2_7_21_1","first-page":"74","article-title":"\u2018Unani Description of Sumaq (Rhus coriaria Linn.) and its Scientific Report\u2019","volume":"13","author":"Ahmad H.","year":"2013","journal-title":"Global J. Med. Res."},{"key":"e_1_2_7_22_1","first-page":"2077","article-title":"\u2018Orally Administration Effect of Sumac on Blood Sugar in Rat\u2019","volume":"5","author":"Mirhadi K.","year":"2011","journal-title":"Adv. Environ. Biol."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-8741(91)90072-L"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(00)00399-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0367-326X(00)00277-X"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00253-2"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00182-4"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00029-6"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.12.035"},{"key":"e_1_2_7_30_1","unstructured":"T.\u2005H. Wetheril M. Pala \u2018Herbs and spices indigenous to Turkey\u2019 in \u2018Spices Herbs and Edible Fungi: Developments in Food Science\u2019 Ed. G. Charalambous Elsevier Science B.\u2005V. Amsterdam 1994 Vol. 34 pp. 285\u2013307."},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-4565.2004.00506.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1356186308008663"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.12816\/0008245"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2017.10.002"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201700270"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2016.12.018"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.5121"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2013.794020"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.1993.9698267"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.90410"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2018.07.001"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2006.09.049"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.3923\/pjn.2009.1570.1574"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.06.011"},{"key":"e_1_2_7_45_1","article-title":"\u2018Effects of Rhus coriaria L. hydroalcoholic extract on the lipid and antioxidant profile in high fat diet-induced hepatic steatosis in rats\u2019","author":"Pasavei A. G.","year":"2018","journal-title":"Drug Chem. Toxicol."},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1537-5110(02)00246-5"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2018.07.058"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep13013"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep21144"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11202-3"},{"key":"e_1_2_7_51_1","first-page":"13","article-title":"\u2018Can Rhus coriaria be a potential, treatment for prostate cancer?\u2019","volume":"2","author":"Muazzam A.","year":"2018","journal-title":"Canc. Sci. Oncol."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11081208"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1305377"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjp.2019.06.004"},{"key":"e_1_2_7_55_1","first-page":"233","article-title":"\u2018Cytotoxicity and antiangiogenic effects of Rhus coriaria, Pistacia vera and Pistacia khinjuk oleoresin methanol extracts\u2019","volume":"10","author":"Mirian M.","year":"2015","journal-title":"Res. Pharm. Sci."},{"key":"e_1_2_7_56_1","first-page":"5694","article-title":"\u2018Phenolic content and biological activities of Rhus coriaria var. Zebaria, Fresen\u2019","volume":"27","author":"Mohammed F. S.","year":"2018","journal-title":"Fresenius Environ. Bull."},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1049\/iet-nbt.2017.0080"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods8040139"},{"key":"e_1_2_7_59_1","first-page":"1","article-title":"\u2018Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants\u2019","author":"Jamous R. M.","year":"2018","journal-title":"J. Evid.-Based Complement. Altern. Med."},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.2018-14613"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4144"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2016.1145702"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410500520186"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.960943"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/0972060X.2018.1462739"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2016.08.024"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6674"},{"key":"e_1_2_7_68_1","first-page":"269","article-title":"\u2018Effect of Rhus coriaria L. water extract on five common oral bacteria and bacterial biofilm formation on orthodontic wire\u2019","volume":"6","author":"Vahid-Dastjerdi E.","year":"2014","journal-title":"Iran. J. Microbiol."},{"key":"e_1_2_7_69_1","first-page":"513","article-title":"\u2018Down-regulation of glycosyl transferase genes in Streptococcus mutans by Punica granatum L. flower and Rhus coriaria L. fruit water extracts\u2019","volume":"15","author":"Vahid-Dastjerdi E.","year":"2016","journal-title":"Iran. J. Pharm. Res."},{"key":"e_1_2_7_70_1","first-page":"390","article-title":"\u2018Screening in\u2005vitro and in\u2005vivo the antibacterial activity of Rhus coriaria extract against S. aureus\u2019","volume":"15","author":"Akrayi H. F. S.","year":"2013","journal-title":"Int. J. Recent Res. Appl. Studies"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1995-7645(10)60064-8"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5861537"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb00760.x"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13068"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.664"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines6020048"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.111829"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-775720140288"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.08.017"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1185797"},{"key":"e_1_2_7_81_1","first-page":"988","article-title":"\u2018Lipid-lowering effect of Rhus coriaria L. (sumac) fruit extract in hypercholesterolemic rats\u2019","volume":"66","author":"Shafiei M.","year":"2011","journal-title":"Pharmazie"},{"key":"e_1_2_7_82_1","first-page":"97","article-title":"\u2018Effect of sumac (Rhus coriaria) extract on blood lipid profile in white Wistar rats\u2019","volume":"2","author":"Soltani H. R.","year":"2017","journal-title":"Intern. Med. Med. Invest. J."},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.21608\/bnni.2017.6726"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2017.1394237"},{"key":"e_1_2_7_85_1","first-page":"1147","article-title":"\u2018Factors Affecting Chemical Variability of Essential Oils: A Review of Recent Developments\u2019","volume":"4","author":"Barra A.","year":"2009","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_86_1","doi-asserted-by":"crossref","first-page":"e1900553","DOI":"10.1002\/cbdv.201900553","article-title":"\u2018Aroma profile of two populations of Salvia verbenaca collected from two bio-geographical zones from Jordan\u2019","volume":"17","author":"Al-Jaber H. I.","year":"2019","journal-title":"Chem. Biodiversity"}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.201900561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201900561","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.201900561","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.201900561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T08:06:43Z","timestamp":1694074003000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.201900561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":86,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/cbdv.201900561"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.201900561","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"2019-10-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e1900561"}}