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Histone deacetylases including SIRT1 have significant role to protect neuron from hyperglycemia induced damage. Formononetin (FMNT) is known for its effect to control hyperglycemia and also activate SIRT1. In present study, we evaluated effect of FMNT as SIRT1 activator in type 2 diabetic neuropathy. Type 2 diabetic neuropathy was induced in rats by modification of diet for 15\u2005days using high fat diet and administration of streptozotocin (35\u2005mg\/kg\/day, <jats:italic>i.\u2009p<\/jats:italic>.). FMNT treatment was initiated after confirmation of type 2 diabetes. Treatment was given for 16 weeks at 10, 20 and 40\u2005mg\/kg\/day dose orally. FMNT treatment\u2010controlled hypoglycemia and reduced insulin resistance significantly in diabetic animals. FMNT treatment reduced oxidative stress in sciatic nerve tissue. FMNT treatment also reduced thermal hyperalgesia and mechanical allodynia significantly. It improved conduction velocity in nerve and unregulated SIRT1 and NGF expression in sciatic nerve tissue. Results of present study indicate that continuous administration of FMNT protected diabetic animals from hyperglycemia induced neuronal damage by controlling hyperglycemia and increasing SIRT1 and NGF expression in nerve tissue. Thus, FMNT can be an effective candidate for treatment of type 2 diabetic neuropathy.<\/jats:p>","DOI":"10.1002\/cbdv.202000162","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T11:05:41Z","timestamp":1590577541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Formononetin Ameliorates Diabetic Neuropathy by Increasing Expression of SIRT1 and NGF"],"prefix":"10.1002","volume":"17","author":[{"given":"Manisha J.","family":"Oza","sequence":"first","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management, SVKM's NMIMS  V.L.Mehta Road, Vile Parle (W) Mumbai 400056 India"},{"name":"SVKM's Dr. Bhanuben Nanavati College of Pharmacy, Vile Parle (W)  Mumbai 400056 India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1686-7907","authenticated-orcid":false,"given":"Yogesh A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"Shobhaben Pratapbhai Patel School of Pharmacy &amp; Technology Management, SVKM's NMIMS  V.L.Mehta Road, Vile Parle (W) Mumbai 400056 India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"e_1_2_9_1_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2018.04.001"},{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-018-0309-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.02.005"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8641942"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/gt.2012.90"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5541-09.2010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100938"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.021"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/38664"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2013.12.001"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.073"},{"key":"e_1_2_9_12_1","first-page":"7152","article-title":"\u2018Intrathecal SRT1720, a SIRT1 agonist, exerts anti-hyperalgesic and anti-inflammatory effects on chronic constriction injury-induced neuropathic pain in rats\u2019","volume":"8","author":"Lv C.","year":"2015","journal-title":"Int. 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