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Curcumin can inhibit bacterial virulence factors, inhibit bacterial biofilm formation and prevent bacterial adhesion to host receptors through the bacterial quorum sensing regulation system. As a photosensitizer, curcumin acts under blue light irradiation to induce phototoxicity and inhibit bacterial growth. Moreover, it can exert a synergistic antibacterial effect with other antibacterial substances. In this review, we summarize the research progress on the antibacterial mechanism of curcumin based on five targeting structures and two modes of action. Our discussion provides a theoretical basis and technical foundation for the development and application of natural antibacterial agents.<\/jats:p>","DOI":"10.1002\/cbdv.202000171","type":"journal-article","created":{"date-parts":[[2020,6,13]],"date-time":"2020-06-13T03:49:25Z","timestamp":1592020165000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":508,"title":["Antibacterial Mechanism of Curcumin: A Review"],"prefix":"10.1002","volume":"17","author":[{"given":"Dantong","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Light Industry and Food Engineering Guangxi University Nanning 530004 P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4368-9499","authenticated-orcid":false,"given":"Chongxing","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Light Industry and Food Engineering Guangxi University Nanning 530004 P. R. 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