{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T02:32:03Z","timestamp":1784169123532,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","award":["CU-GR_62_01_23_01"],"award-info":[{"award-number":["CU-GR_62_01_23_01"]}],"id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chemistry &amp; Biodiversity"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Bioassay\u2010guided fractionation was conducted on dichloromethane extract from the rhizomes of <jats:italic>Globba schomburgkii<\/jats:italic> <jats:sc>Hook.f.,<\/jats:sc> which have previously been reported as the part with the highest antibacterial activity. 10 fractions and 20 sub\u2010fractions were obtained and evaluated for their potency against various strains of bacteria. The most active sub\u2010fractions were 8 times more effective against <jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Micrococcus luteus<\/jats:italic> than the original crude extract. Moreover, two pure compounds, namely petasol and (<jats:italic>E<\/jats:italic>)\u201015,16\u2010dinorlabda\u20108(17),11\u2010dien\u201013\u2010one, were successfully isolated and characterized for the first time from this plant species. Untargeted compound analysis of all fractions and sub\u2010fractions was performed by gas chromatography hyphenated with mass spectrometry, leading to positive identification of 167 compounds according to comparison with the mass spectrum and retention index database, 137 of which have never been reported for <jats:italic>G. schomburgkii<\/jats:italic>. The correlation between antibacterial activity and composition of each fraction suggests that the bioactive compounds could be 4,8\u2010<jats:italic>\u03b2<\/jats:italic>\u2010epoxycaryophyllene, methyl isocostate, (<jats:italic>E<\/jats:italic>)\u2010labda\u20108(17),12\u2010diene\u201015,16\u2010dial, <jats:italic>\u03b1<\/jats:italic>\u2010kessyl acetate, zederone, clovanediol, ledene oxide\u2010(I), alantolactone, or 8<jats:italic>\u03b1<\/jats:italic>,11\u2010elemadiol.<\/jats:p>","DOI":"10.1002\/cbdv.202000173","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T14:19:51Z","timestamp":1592230791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bioassay\u2010Guided Fractionation, Chemical Compositions and Antibacterial Activity of Extracts from Rhizomes of <i>Globba schomburgkii<\/i> H<scp>ook.f.<\/scp>"],"prefix":"10.1002","volume":"17","author":[{"given":"Naruemon","family":"Suekaew","sequence":"first","affiliation":[{"name":"Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science Chulalongkorn University  Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarisa","family":"Na Pombejra","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Science Chulalongkorn University  Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chadin","family":"Kulsing","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Chulalongkorn University  Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeerapat","family":"Doungchawee","sequence":"additional","affiliation":[{"name":"Department of Food and Pharmaceutical Chemistry, Faculty of Pharmaceutical Science Chulalongkorn University  Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7236-0625","authenticated-orcid":false,"given":"Tanatorn","family":"Khotavivattana","sequence":"additional","affiliation":[{"name":"Center of Excellence in Natural Products Chemistry, Department of Chemistry, Faculty of Science Chulalongkorn University  Bangkok 10330 Thailand"},{"name":"Research Unit for Metabolic Bone Disease in CKD Patients Chulalongkorn University  Bangkok 10330 Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,28]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01068"},{"key":"e_1_2_7_2_1","first-page":"277","article-title":"\u2018The antibiotic resistance crisis\u2019","volume":"40","author":"Ventola C. L.","year":"2015","journal-title":"Pharm. Ther."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.7b00283"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1519709"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.07.041"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbdv.201900057"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3732\/ajb.91.1.100"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.48048\/wjst.2018.3507","article-title":"\u2018In vitro propagation of Globba schomburgkii Hook.f. via bulbil explants\u2019","volume":"15","author":"Saensouk P.","year":"2017","journal-title":"Walailak J. Sci. Tech."},{"key":"e_1_2_7_9_1","first-page":"157","article-title":"\u2018Comparing growth and physiological responses of Globba schomburgkii Hook.f. and Globba marantina L. under hydroponic and soil conditions\u2019","volume":"30","author":"Phantong P.","year":"2018","journal-title":"Emir. J. Food Agric."},{"key":"e_1_2_7_10_1","first-page":"6579","article-title":"\u2018Antimicrobial and antioxidant activities of tuber extracts of Globba bulbifera\u2019","volume":"2","author":"Rao N.","year":"2013","journal-title":"World J. Pharm. Pharm. Sci."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/10412905.2012.692915"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-57486-w"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(83)80099-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10600-013-0447-x"},{"key":"e_1_2_7_15_1","first-page":"156","article-title":"\u2018Petasins from the rhizomes of Ligularia fischeri and its derivatives\u2019","volume":"8","author":"Wang C.","year":"2014","journal-title":"Rec. Nat. Prod."},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16064539"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21060749"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1351075"},{"key":"e_1_2_7_19_1","first-page":"1547","article-title":"\u2018Anti-inflammatory mechanisms of compounds from Curcuma mangga rhizomes using RAW264.7 macrophage cells\u2019","volume":"5","author":"Kaewkroek K.","year":"2010","journal-title":"Nat. Prod. Commun."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.06.029"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.07.053"},{"key":"e_1_2_7_22_1","first-page":"63","article-title":"\u2018Zederone from the rhizomes of Zingiber zerumbet and its anti-staphylococcal activity\u2019","volume":"9","author":"Kader M. G.","year":"2010","journal-title":"Bol. Latinoam. Caribe Plant. Med. Aromat."},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2013.879306"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/248532"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1039\/C0OB00467G"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(88)83115-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)80947-X"},{"key":"e_1_2_7_28_1","unstructured":"S.\u2005J. Cavalieri R.\u2005J. Harbeck Y.\u2005S. McCarter J.\u2005H. Ortez I.\u2005D. Rankin R.\u2005L. Sauter S.\u2005E. Sharp C.\u2005A. Spiegel in \u2018Manual of antimicrobial susceptibility testing\u2019 Ed. M.\u2005B. Coyle American Society for Microbiology Washington DC 2005 Vol. 25 pp. 39\u201362."}],"container-title":["Chemistry &amp; Biodiversity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fcbdv.202000173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202000173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cbdv.202000173","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cbdv.202000173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T07:44:13Z","timestamp":1693899853000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cbdv.202000173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,28]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/cbdv.202000173"],"URL":"https:\/\/doi.org\/10.1002\/cbdv.202000173","archive":["Portico"],"relation":{},"ISSN":["1612-1872","1612-1880"],"issn-type":[{"value":"1612-1872","type":"print"},{"value":"1612-1880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,28]]},"assertion":[{"value":"2020-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2000173"}}