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Three chosen coumarin derivatives, differing in the substituent (<jats:italic>sec<\/jats:italic>\u2010butylamino, hexadecylamino, or benzylamino) at position 4, at the doses of 25, 50 and 100\u2005mg kg<jats:sup>\u20131<\/jats:sup>, were evaluated in light\/dark, open\u2010field, horizontal wire and diazepam\u2010induced sleep models using male BALB\/c mice. Depending on the applied dose, all three tested coumarins displayed a noteworthy anxiolytic\u2010like effect. 4\u2010(<jats:italic>sec<\/jats:italic>\u2010Butylamino)\u20103\u2010nitro\u20102<jats:italic>H<\/jats:italic>\u2010chromen\u20102\u2010one and 4\u2010(hexadecylamino)\u20103\u2010nitro\u20102<jats:italic>H<\/jats:italic>\u2010chromen\u20102\u2010one could be recognized as true anxiolytics in the lowest applied dose, based on three tests, without exerting any sedative effects. Thus, the 3\u2010nitrocoumarin core deserves further chemical diversity exploration in the \u2018antianxiety\u2019 direction.<\/jats:p>","DOI":"10.1002\/cbdv.202000206","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T17:33:35Z","timestamp":1587144815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Anxiolytic\u2010Like Action of Selected 4\u2010(Alkylamino)\u20103\u2010nitrocoumarin Derivatives in BALB\/c Mice"],"prefix":"10.1002","volume":"17","author":[{"given":"Pavle J.","family":"Randjelovi\u0107","sequence":"first","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ni\u0161  Zorana \u0110in\u0111i\u0107a 81 18000 Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1342-7567","authenticated-orcid":false,"given":"Niko S.","family":"Radulovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Sciences and Mathematics University of Ni\u0161  Vi\u0161egradska 33 18000 Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikola M.","family":"Stojanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ni\u0161  Zorana \u0110in\u0111i\u0107a 81 18000 Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidoslav S.","family":"Deki\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Sciences University of Pri\u0161tina \u2013 Kosovska Mitrovica  Lole Ribara 29 38220 Kosovska Mitrovica Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biljana R.","family":"Deki\u0107","sequence":"additional","affiliation":[{"name":"Faculty of Sciences University of Pri\u0161tina \u2013 Kosovska Mitrovica  Lole Ribara 29 38220 Kosovska Mitrovica Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenad I.","family":"Stojiljkovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ni\u0161  Zorana \u0110in\u0111i\u0107a 81 18000 Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja M.","family":"Ili\u0107","sequence":"additional","affiliation":[{"name":"Department of Physiology Faculty of Medicine University of Ni\u0161  Zorana \u0110in\u0111i\u0107a 81 18000 Ni\u0161 Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"R. 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