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Their structures were characterized by various spectroscopic methods including IR, NMR (<jats:sup>1<\/jats:sup>H, <jats:sup>31<\/jats:sup>P, <jats:sup>13<\/jats:sup>C), mass spectrometry and single crystal X\u2010ray diffraction. The newly synthesized phosphorus\u2010containing oximes were screened for their <jats:italic>in\u2005vitro<\/jats:italic> antimicrobial activity against Gram\u2010positive bacteria (<jats:italic>Staphylococcus aureus<\/jats:italic> and <jats:italic>Bacillus subtilis<\/jats:italic>), Gram\u2010negative bacteria (<jats:italic>Escherichia coli<\/jats:italic> and <jats:italic>Salmonella typhimurium<\/jats:italic>) and fungal strains (<jats:italic>Candida albicans<\/jats:italic> and <jats:italic>Candida glabrata<\/jats:italic>). The biological assays showed that all the studied compounds exhibited high antibacterial and antifungal activities at only 0.1\u20132.1\u2005\u03bcg\/mL. <jats:italic>In silico<\/jats:italic> molecular docking studies in FabH enzyme active site were performed in order to predict the possible interaction modes and binding energies of the drug candidates at the molecular level.<\/jats:p>","DOI":"10.1002\/cbdv.202000217","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T20:21:23Z","timestamp":1589833283000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Synthesis, Antimicrobial Activity and Molecular Docking Study of Novel <i>\u03b1<\/i>\u2010(Diphenylphosphoryl)\u2010 and <i>\u03b1<\/i>\u2010(Diphenylphosphorothioyl)cycloalkanone Oximes"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-1603","authenticated-orcid":false,"given":"Nejib","family":"Jebli","sequence":"first","affiliation":[{"name":"University of Carthage Faculty of Sciences of Bizerte Laboratory of Hetero-Organic Compounds and Nanostructured Materials (LR18ES11)  CP 7021- Jarzouna Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"Hamimed","sequence":"additional","affiliation":[{"name":"University of Carthage Faculty of Sciences of Bizerte Laboratory of Biochemistry and Molecular Biology  7021 Jarzouna Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristof","family":"Van Hecke","sequence":"additional","affiliation":[{"name":"XStruct Department of Inorganic and Physical Chemistry  Krijgslaan 281-S3 CP 9000-Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean\u2010Fran\u00e7ois","family":"Cavalier","sequence":"additional","affiliation":[{"name":"Aix-Marseille Universit\u00e9  CNRS, LISM, IMM FR CP 3479- Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soufiane","family":"Touil","sequence":"additional","affiliation":[{"name":"University of Carthage Faculty of Sciences of Bizerte Laboratory of Hetero-Organic Compounds and Nanostructured Materials (LR18ES11)  CP 7021- Jarzouna Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,10]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"D.\u2005L. 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