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Thus, the aim of this work was to evaluate<jats:italic>in\u2005vitro<\/jats:italic>schistosomicidal activity of the hexanes\/dichloromethane 1\u2009:\u20091 extract of Brazilian green propolis (Pex), as well as its major isolated compounds artepillin C, caffeic acid, coumaric acid and drupanin against<jats:italic>Schistosoma mansoni<\/jats:italic>. The Pex was active by displaying an IC<jats:sub>50<\/jats:sub>value of 36.60 (26.26\u201351.13)\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>at 72 h against adult worms of<jats:italic>S. mansoni<\/jats:italic>. The major isolated compounds were inactive with IC<jats:sub>50<\/jats:sub>values &gt;100\u2005\u03bcM, however, the combination of the isolated compounds (CM) in the same range found in the extract was active with an IC<jats:sub>50<\/jats:sub>value of 41.17 (39.89\u201342.46)\u2005\u03bcg\u2009mL<jats:sup>\u22121<\/jats:sup>at 72 h. Pex and CM induced alteration in the tegument of<jats:italic>S. mansoni<\/jats:italic>, and caffeic acid caused alteration in egg's maturation. Pex displayed<jats:italic>in\u2005vitro<\/jats:italic>activity against adult worms\u2019 and eggs\u2019 viability of<jats:italic>S. mansoni<\/jats:italic>, which opens new perspectives to better understand the synergistic and\/or additive effects promoted by both Pex extract and CM against schistosomiasis features.<\/jats:p>","DOI":"10.1002\/cbdv.202000277","type":"journal-article","created":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T01:44:25Z","timestamp":1592963065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Uncovering Biological Application of Brazilian Green Propolis: A Phenotypic Screening against<i>Schistosoma mansoni<\/i>"],"prefix":"10.1002","volume":"17","author":[{"given":"Lucas","family":"A. de L. Paula","sequence":"first","affiliation":[{"name":"Research Group on Natural Products Center for Research in Sciences and Technology University of Franca Avenida Dr. Armando Salles of Oliveira, CEP 14404-600 Franca SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario F. 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