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HR\u2010ESI\u2010MS, 1D and 2D NMR spectroscopic methods were used in the elucidation of the compounds. Bisaprasin, a biphenylic dimer of psammaplin A, showed moderate activity with IC<jats:sub>50<\/jats:sub> at 19\u00b15 and 29\u00b16\u2005\u03bcM against <jats:italic>Trypanzoma cruzi<\/jats:italic> Tulahuen C4, and the lethal human malaria species <jats:italic>Plasmodium falciparum<\/jats:italic> clone 3D7, respectively, while psammaplins A and D exhibited low activity against both parasites. This is the first report of the antimalarial and antitrypanosomal activity of the psammaplin\u2010type compounds. Additionally, the biosynthesis hypotheses of three natural products were proposed.<\/jats:p>","DOI":"10.1002\/cbdv.202000335","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T13:13:26Z","timestamp":1595423606000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Antiparasitic Activity of Bromotyrosine Alkaloids and New Analogues Isolated from the Fijian Marine Sponge <i>Aplysinella rhax<\/i>"],"prefix":"10.1002","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3153-4323","authenticated-orcid":false,"given":"Emmanuel T.","family":"Oluwabusola","sequence":"first","affiliation":[{"name":"Marine Biodiscovery Centre, Department of Chemistry University of Aberdeen  AB24 3UE Old Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jioji N.","family":"Tabudravu","sequence":"additional","affiliation":[{"name":"School of Forensic and Applied Sciences, Faculty of Science and Technology University of Central Lancashire  Preston PR1 2HE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid S.","family":"Al Maqbali","sequence":"additional","affiliation":[{"name":"School of Forensic and Applied Sciences, Faculty of Science and Technology University of Central Lancashire  Preston PR1 2HE UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Annang","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Parque Tecnol\u00f3gico de Ciencias de la Salud  Avenida del Conocimiento 34.18016- Armilla Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guiomar","family":"P\u00e9rez\u2010Moreno","sequence":"additional","affiliation":[{"name":"Instituto de Parasitolog\u00eda y Biomedicina \u2018L\u00f3pez-Neyra', Consejo Superior de Investigaciones Cient\u00edficas, Parque Tecnol\u00f3gico de Ciencias de la Salud  Avenida del Conocimiento, 17 18016- Armilla Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Reyes","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n MEDINA, Parque Tecnol\u00f3gico de Ciencias de la Salud  Avenida del Conocimiento 34.18016- Armilla Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Jaspars","sequence":"additional","affiliation":[{"name":"Marine Biodiscovery Centre, Department of Chemistry University of Aberdeen  AB24 3UE Old Aberdeen UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,29]]},"reference":[{"key":"e_1_2_7_1_1","unstructured":"World Health Organization \u2018World malaria report 2019\u2019 Gen 2019 1\u2013232."},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60061-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.333.6045.934"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10741-010-9211-5"},{"key":"e_1_2_7_5_1","unstructured":"Fact sheet about malaria. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria (accessed Jun 22 2020)."},{"key":"e_1_2_7_6_1","unstructured":"Chagas disease. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/chagas-disease-(American-trypanosomiasis) (accessed Jun 22 2020)."},{"key":"e_1_2_7_7_1","unstructured":"World Health Organisation \u2018Artemisinin resistance and artemisinin-based combination therapy efficacy\u2019 World Malaria Report 2019 1\u20136."},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2875-8-31","article-title":"\u2018The last man standing is the most resistant: eliminating artemisinin-resistant malaria In Cambodia\u2019","volume":"8","author":"Maude R.","year":"2009","journal-title":"Malar. 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