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Samples were analyzed by NMR, GC\/MS, triterpenes quantification, and MTT reduction assay. Morphological, cell cycle, mitochondrial membrane potential and caspases 3\/7 analyses were performed for the dichloromethane and ethanol fractions, and selectivity index for the dichloromethane fraction. NMR analysis presented characteristic signals of terpenes and steroids, data were confirmed by the quantification of triterpenes and GC\/MS analysis. MTT reduction assay demonstrated that HL\u201060 was the most sensitive cell lineage against dichloromethane and ethanol fractions. Compounds of these matrices caused morphological changes compatible with apoptosis induction, altered cell cycle, increment of depolarized population cells and activation of caspases 3\/7. Selectivity indices were higher than 22.44. Bioguided\u2010fractionation study showed that samples of the latex of <jats:italic>E. umbellata<\/jats:italic> raised the activity of the phytocomplex against leukemic cells, and the cytotoxicity can be associated with an apoptosis pathway.<\/jats:p>","DOI":"10.1002\/cbdv.202000369","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T15:13:58Z","timestamp":1594307638000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Enriched Terpenes Fractions of the Latex of <i>Euphorbia umbellata<\/i> Promote Apoptosis in Leukemic Cells"],"prefix":"10.1002","volume":"17","author":[{"given":"Luiza Stolz","family":"Cruz","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences State University of Ponta Grossa  General Carlos Cavalcanti Avenue 4748 84900-030 Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Cristine","family":"Kanunfre","sequence":"additional","affiliation":[{"name":"Department of General Biology State University of Ponta Grossa  General Carlos Cavalcanti Avenue 4748 84900-030 Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn Assis","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences State University of Ponta Grossa  General Carlos Cavalcanti Avenue 4748 84900-030 Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Alves","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences State University of Ponta Grossa  General Carlos Cavalcanti Avenue 4748 84900-030 Ponta Grossa Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Stolz","family":"Cruz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical 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Curitiba Paran\u00e1 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research University of Mississippi  MS 38677 Oxford MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikhlas Ahmad","family":"Khan","sequence":"additional","affiliation":[{"name":"National Center for Natural Products Research University of Mississippi  MS 38677 Oxford MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-5802","authenticated-orcid":false,"given":"Fl\u00e1vio Lu\u00eds","family":"Beltrame","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences State University of Ponta Grossa  General Carlos Cavalcanti Avenue 4748 84900-030 Ponta Grossa Paran\u00e1 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