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The aim of this study was to investigate the potential anti\u2010inflammatory effects of <jats:italic>H. lateritium<\/jats:italic> extracts and its isolated steroids: fasciculic acid B, fasciculol E, fasciculol C, lanosta\u20107,9(11)\u2010diene\u201012<jats:italic>\u03b2<\/jats:italic>,21<jats:italic>\u03b1<\/jats:italic>\u2010epoxy\u20102<jats:italic>\u03b1<\/jats:italic>,3<jats:italic>\u03b2<\/jats:italic>,24<jats:italic>\u03b2<\/jats:italic>,25\u2010tetraol, fasciculol F, and demethylincisterol A2. Organic (hexane, chloroform and 50\u2009% methanol) and water extracts of <jats:italic>H. lateritium<\/jats:italic> were subjected to <jats:italic>in\u2005vitro<\/jats:italic> assays to determine pro\u2010inflammatory protein levels, such as cyclooxygenase\u20102 (COX\u20102), cytosolic prostaglandin E2 synthase (cPGES), and antioxidant nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2). Fungal extracts demonstrated significant activities on pro\u2010inflammatory protein levels with minor differences among the activities of the fractions of different polarities. All the compounds proved to exert notable inhibitory properties on COX\u20102 and were capable to stimulate the Nrf2 pathway. Fungal extracts and the compounds exerted no cytotoxic activities on RAW 264.7 cells.<\/jats:p>","DOI":"10.1002\/cbdv.202000391","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T10:05:19Z","timestamp":1592561119000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Extracts and Steroids from the Edible Mushroom <i>Hypholoma lateritium<\/i> Exhibit Anti\u2010Inflammatory Properties by Inhibition of COX\u20102 and Activation of Nrf2"],"prefix":"10.1002","volume":"17","author":[{"given":"Attila","family":"V\u00e1nyol\u00f3s","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Interdisciplinary Excellence Center University of Szeged  E\u00f6tv\u00f6s u. 6. H-6720 Szeged Hungary"},{"name":"Department of Pharmacognosy Semmelweis University  \u00dcll\u0151i u. 26 H-1085 Budapest Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u017cena","family":"Muszy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College  9 Medyczna Street 30-688 Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bayar","family":"Chuluunbaatar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Interdisciplinary Excellence Center University of Szeged  E\u00f6tv\u00f6s u. 6. H-6720 Szeged Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Gdula\u2010Argasi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Radioligands, Faculty of Pharmacy Jagiellonian University Medical College  9 Medyczna Street 30-688 Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Ka\u0142a","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Botany, Faculty of Pharmacy, Jagiellonian University Medical College  9 Medyczna Street 30-688 Krak\u00f3w Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"Hohmann","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Interdisciplinary Excellence Center University of Szeged  E\u00f6tv\u00f6s u. 6. H-6720 Szeged Hungary"},{"name":"Interdisciplinary Center of Natural Products University of Szeged  E\u00f6tv\u00f6s u. 6. 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