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This study aimed to explore the protective effect of nucleosides\u2010rich extract from <jats:italic>Cordyceps cicadae<\/jats:italic> (NRCE) against CISP\u2010induced testicular damage in rats. Rats were subjected to prophylactic oral administration of NRCE (50, 100 and 400\u2005mg\/kg body weight\/day) for 7\u2005days prior to testicular toxicity induced by CISP (10\u2005mg\/kg, ip) and were sacrificed after 72\u2005h post\u2010CISP injection. Cisplatin caused significant deficits in sperm count, viability and motility, testosterone and follicle stimulating hormone (FSH) compared to normal control. It depressed testicular activities of glutathione peroxidase (GSH\u2010Px), superoxide dismutase (SOD), catalase (CAT), total antioxidant content (TAC), whereas malondialdehyde (MDA) increased remarkably. CISP considerably increased tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) and interleukin\u2010one beta (IL\u20101\u03b2) with alterations in testis histology compared to normal control. Interestingly, NRCE pretreatment inhibited the CISP\u2010induced alterations in reproductive indices, restored the antioxidant activities in testes as well as inflammatory mediators and histology comparable to control. Our findings demonstrate that NRCE could prevent CISP testicular damage via inhibition of oxidative stress and pro\u2010inflammation in rats.<\/jats:p>","DOI":"10.1002\/cbdv.202000671","type":"journal-article","created":{"date-parts":[[2020,10,2]],"date-time":"2020-10-02T17:20:08Z","timestamp":1601659208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Protective Effects of Nucleosides\u2010Rich Extract from <i>Cordyceps cicadae<\/i> against Cisplatin Induced Testicular Damage."],"prefix":"10.1002","volume":"17","author":[{"given":"Ling","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Reproductive Center the 940th Hospital of Joint Logistics Support Force of Chinese PLA  Lanzhou 730050 P. R. 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