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The aim of this research was to find whether non\u2010aggregating fragments 1\u20137, 8\u201312, 13\u201317 and 28\u201332 of amylin would inhibit the aggregation of the amyloidogenic cores 18\u201322, 23\u201327, 33\u201337 of hormone. In the study of the inhibitory potential of non\u2010aggregating amylin fragments, a set of independent methods were used to study aggregation properties (spectroscopic and fluorescence studies with the use of indicators, microscopic studies, circular dichroism studies) and the method of prediction of aggregation properties. The performed research allowed to select the cyclic fragment (1\u20137) H\u2010KCNTATC\u2010OH with disulfide bond as an inhibitor capable of inhibiting the aggregation of all amyloidogenic cores 18\u201322, 23\u201327, 33\u201337 of the hormone. Additionally, it was found that this peptide inhibits insulin hot spot aggregation, which may indicate its universal utility in inhibiting the process of aggregation of hormones regulating carbohydrate metabolism directly related to the development of diabetes. Research on the possibility of the extensive use of the cyclic fragment (1\u20137) of H\u2010KCNTATC\u2010OH as a peptide inhibitor of the polypeptide\/protein aggregation process is ongoing.<\/jats:p>","DOI":"10.1002\/cbdv.202100034","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T11:03:39Z","timestamp":1615287819000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Non\u2010Aggregating Amylin Fragments as an Inhibitors of the Aggregation Process of Susceptible to Aggregation Fragments 18\u201322, 23\u201327, and 33\u201337 of Hormone"],"prefix":"10.1002","volume":"18","author":[{"given":"Andrzej","family":"Fraczyk","sequence":"first","affiliation":[{"name":"Institute of Applied Computer Science Lodz University of Technology  Stefanowskiego \u0141\u00f3d\u017a, 18\/22 90-537 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukasz","family":"Janczewski","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology  Zeromskiego 116 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Wasko","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology  Zeromskiego 116 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamil","family":"Rozniakowski","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology  Zeromskiego 116 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krystian","family":"Galecki","sequence":"additional","affiliation":[{"name":"Institute of General Food Chemistry Faculty of Biotechnology and Food Sciences Lodz University of Technology  Stefanowskiego 4\/10 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zbigniew J.","family":"Kaminski","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology  Zeromskiego 116 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4581-947X","authenticated-orcid":false,"given":"Beata","family":"Kolesinska","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry Faculty of Chemistry Lodz University of Technology  Zeromskiego 116 90-924 Lodz Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_7_1_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.13.5036"},{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/13506120701460923"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805957106"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2010.526812"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2007.01.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.10.029"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja072157y"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00529-7"},{"key":"e_1_2_7_10_1","first-page":"305","article-title":"A Review of Pramlintide in the Management of Diabetes\u2019","volume":"1","author":"Messer C.","year":"2009","journal-title":"Clin. 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