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The extraction was performed ultrasound\u2010assisted, and UHPLC\/MS analysis was in positive mode ionization. The anti\u2010inflammatory activity of the extracts and miquelianin were assayed at concentrations 0.001\u201310\u2005\u03bcg\/mL by chemotaxis on rat polymorphonuclear neutrophils. The antihypertensive activity was performed by angiotensin\u2010converting enzyme (ACE) inhibition. From the nineteen proposed compounds, six of them are described for the first time in this genus. The extracts displayed antichemotactic effect with a reduction of 100\u2009% of the neutrophil migration, <jats:italic>in\u2005vitro<\/jats:italic>, in most concentrations. The ACE\u2010inhibition presented results ranging from 19.58 to 22.82\u2009%. In conclusion, <jats:italic>C. lindmaniana<\/jats:italic> and <jats:italic>C. urbaniana<\/jats:italic> extracts contain a rich diversity of flavonoids and display <jats:italic>in\u2005vitro<\/jats:italic> anti\u2010inflammatory and antihypertensive potential. Thus, this study could serve as a scientific baseline for further investigation, on developmental novel products with therapeutic actions.<\/jats:p>","DOI":"10.1002\/cbdv.202100041","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T17:52:51Z","timestamp":1621273971000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Polyphenolic Composition and <i>in Vitro<\/i> Antihypertensive and Anti\u2010Inflammatory Effects of <i>Cuphea lindmaniana<\/i> and <i>Cuphea urbaniana<\/i>"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-7085","authenticated-orcid":false,"given":"Mar\u00ed C.","family":"Santos","sequence":"first","affiliation":[{"name":"Department of Pharmacy Pharmacognosy Laboratory Federal University of Rio Grande do Sul  Porto Alegre 90610-000 Brazil"},{"name":"Postgraduate Program in Pharmaceutical Sciences Federal University of Rio Grande do Sul  Porto Alegre Rio Grande do Sul 90610-000 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krissie D.","family":"Soares","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Pharmacognosy Laboratory Federal University of Rio Grande do Sul  Porto Alegre 90610-000 Brazil"},{"name":"Postgraduate Program in Pharmaceutical Sciences Federal University of Rio Grande do Sul  Porto Alegre Rio Grande do Sul 90610-000 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betina M.","family":"Beltrame","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Pharmacognosy Laboratory Federal University of Rio Grande do Sul  Porto Alegre 90610-000 Brazil"},{"name":"Postgraduate Program in Pharmaceutical Sciences Federal University of Rio Grande do Sul  Porto Alegre Rio Grande do Sul 90610-000 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natally S. 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